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How to Maintain Serum Antibody Titers?

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Air date: Wednesday, March 9, 2016, 4:15:00 PM
Time displayed is Eastern Time, Washington DC Local
Views: Total views: 301 (54 Live, 247 On-demand)
Category: Immunology
Runtime: 01:01:50
Description: Immunology Interest Group

David Allman is an Associate Professor of Pathology and Laboratory Medicine in the Department of Pathology and Laboratory Medicine of the Perelman School of Medicine at the University of Pennsylvania. He described what are now called transitional B cells during his PhD. This work showed that B cell maturation and formation of the B cell repertoire is completed in peripheral lymphoid tissues rather than in the bone marrow. Later, working with Warren Pear, he established roles for Notch in T lineage commitment. Recently he has focused on antibody secreting plasma cells, and has discovered that T-cell independent antigens can induce long-lived antibody responses. His laboratory is currently focused on the signaling and epigenetic mechanisms that support the generation of long-lived plasma cells. Abstract: Longitudinal studies of vaccine efficacy indicate antibody responses to many infectious agents last a lifetime; yet antibody responses to less complex protein antigens commonly exhibit relatively short half-lives. To gain insight into this problem, we are working to characterize the cellular and molecular processes underlying the long-term survival of antibody-secreting plasma cells in the bone marrow. Our work reveals that the bone marrow plasma cell pool is highly dynamic, consisting of both short- and long-lived cells characterized by distinct gene expression profiles and derived from a variety of sources beyond the canonical germinal center pathway.
NLM Title: How to maintain serum antibody titers? / David M. Allman ; Immunology Interest Group.
Author: Allman, David M.
National Institutes of Health (U.S.). Immunology Interest Group,
Publisher:
Abstract: (CIT): Immunology Interest Group David Allman is an Associate Professor of Pathology and Laboratory Medicine in the Department of Pathology and Laboratory Medicine of the Perelman School of Medicine at the University of Pennsylvania. He described what are now called transitional B cells during his PhD. This work showed that B cell maturation and formation of the B cell repertoire is completed in peripheral lymphoid tissues rather than in the bone marrow. Later, working with Warren Pear, he established roles for Notch in T lineage commitment. Recently he has focused on antibody secreting plasma cells, and has discovered that T-cell independent antigens can induce long-lived antibody responses. His laboratory is currently focused on the signaling and epigenetic mechanisms that support the generation of long-lived plasma cells. Abstract: Longitudinal studies of vaccine efficacy indicate antibody responses to many infectious agents last a lifetime; yet antibody responses to less complex protein antigens commonly exhibit relatively short half-lives. To gain insight into this problem, we are working to characterize the cellular and molecular processes underlying the long-term survival of antibody-secreting plasma cells in the bone marrow. Our work reveals that the bone marrow plasma cell pool is highly dynamic, consisting of both short- and long-lived cells characterized by distinct gene expression profiles and derived from a variety of sources beyond the canonical germinal center pathway.
Subjects: Antibodies, Viral--blood
Antibody Formation--immunology
B-Lymphocytes--immunology
Plasma Cells--immunology
Publication Types: Lecture
Webcast
 
NLM Classification: WH 200
NLM ID: 101680575
CIT Live ID: 18664
Permanent link: https://videocast.nih.gov/watch=18664

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