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Immune reconstitution syndrome in HIV infection: from bedside to bench

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Air date: Friday, November 13, 2015, 12:00:00 PM
Time displayed is Eastern Time, Washington DC Local
Views: Total views: 307, (66 Live, 241 On-demand)
Category: NIH Director's Seminars
Runtime: 00:53:12
Description:

Director's Seminar Series

HIV infection leads to CD4 lymphopenia and immunosuppression, which can be successfully improved with antiretroviral therapy (ART) but approximately 20 percent of HIV patients initiating ART may develop an aberrant immune response known as immune reconstitution inflammatory syndrome (IRIS). IRIS encompasses the paradoxical worsening of the manifestations of underlying opportunistic diseases (paradoxical IRIS) or the abrupt or atypical presentation of previously occult opportunistic disease (unmasking IRIS) in patients who recently started ART. Importantly, IRIS or paradoxical reactions seem to expand beyond HIV representing a dysregulation of immune responses when immune suppression is abruptly reversed.Our group is studying the clinical predictors, biomarkers and pathogenesis of IRIS through a comprehensive translational program with the aim to develop better strategies for prevention and treatment.

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NLM Title: Immune reconstitution syndrome in HIV infection : from bedside to bench / Irini Sereti.
Author: Sereti, Irini.
National Institutes of Health (U.S.),
Publisher:
Abstract: (CIT): Director's Seminar Series. HIV infection leads to CD4 lymphopenia and immunosuppression, which can be successfully improved with antiretroviral therapy (ART) but approximately 20 percent of HIV patients initiating ART may develop an aberrant immune response known as immune reconstitution inflammatory syndrome (IRIS). IRIS encompasses the paradoxical worsening of the manifestations of underlying opportunistic diseases (paradoxical IRIS) or the abrupt or atypical presentation of previously occult opportunistic disease (unmasking IRIS) in patients who recently started ART. Importantly, IRIS or paradoxical reactions seem to expand beyond HIV representing a dysregulation of immune responses when immune suppression is abruptly reversed.Our group is studying the clinical predictors, biomarkers and pathogenesis of IRIS through a comprehensive translational program with the aim to develop better strategies for prevention and treatment.
Subjects: Antiretroviral Therapy, Highly Active--adverse effects
Clinical Trials as Topic
HIV Infections--complications
Immune Reconstitution Inflammatory Syndrome--pathology
Immune Reconstitution Inflammatory Syndrome--therapy
Publication Types: Lecture
Webcasts
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NLM Classification: WC 503.5
NLM ID: 101673100
CIT Live ID: 17366
Permanent link: https://videocast.nih.gov/launch.asp?19314