NIH VideoCast - Heterogeneity of Tuberculosis

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Heterogeneity of Tuberculosis

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Air date:	Wednesday, March 25, 2015, 4:15:00 PM Time displayed is Eastern Time, Washington DC Local
Views:	Total views: 230 (39 Live, 191 On-demand)
Category:	Immunology
Runtime:	01:02:01
Closed captioning:	Check box to display CC outside of the video Note: You can drag the captioning window around and resize it
Description:	Immunology Interest Group Dr. JoAnne Flynn received her PhD from the University of California, Berkeley, and after completing her post-doctoral fellowships at Scripps and the Albert Einstein College of Medicine, JoAnne joined the faculty at the University of Pittsburgh in 1994. JoAnne’s primary research is focused on studying the host-pathogen interaction. Her laboratory investigates the immune mechanisms that are required for protection against Mycobacterium tuberculosis, the causative agent of tuberculosis (TB). One third of the world is infected with Mycobacterium tuberculosis, yet only 10% will develop clinical disease, while 90% of infected individuals will go on to develop latent TB. However, very little is known about what distinguishes individuals who will develop active TB from those whose infection will remain latent for decades. Using both mouse and non-human primate models, JoAnne’s laboratory has made ground-breaking discoveries defining the local immune responses that determine the clinical outcome of infection. Her research demonstrated that each granuloma within an individual is heterogenous with respect to the total cell number, proportion of T cells, types of cytokines produced and bacterial burden. Her primary goal is to understand why the immune response produces different results in different granulomas, so that the appropriate immune mechanisms can be harnessed to develop effective vaccines. For more information go to http://sigs.nih.gov/immunology/Pages/default.aspx

NLM Title:	Heterogeneity of tuberculosis / JoAnne Flynn.
Author:	Flynn, JoAnne. National Institutes of Health (U.S.). Immunology Interest Group,
Publisher:
Abstract:	(CIT): Immunology Interest Group Dr. JoAnne Flynn received her PhD from the University of California, Berkeley, and after completing her post-doctoral fellowships at Scripps and the Albert Einstein College of Medicine, JoAnne joined the faculty at the University of Pittsburgh in 1994. JoAnne"s primary research is focused on studying the host-pathogen interaction. Her laboratory investigates the immune mechanisms that are required for protection against Mycobacterium tuberculosis, the causative agent of tuberculosis (TB). One third of the world is infected with Mycobacterium tuberculosis, yet only 10% will develop clinical disease, while 90% of infected individuals will go on to develop latent TB. However, very little is known about what distinguishes individuals who will develop active TB from those whose infection will remain latent for decades. Using both mouse and non-human primate models, JoAnne"s laboratory has made ground-breaking discoveries defining the local immune responses that determine the clinical outcome of infection. Her research demonstrated that each granuloma within an individual is heterogenous with respect to the total cell number, proportion of T cells, types of cytokines produced and bacterial burden. Her primary goal is to understand why the immune response produces different results in different granulomas, so that the appropriate immune mechanisms can be harnessed to develop effective vaccines.
Subjects:	Genetic Heterogeneity Tuberculosis--genetics Tuberculosis--immunology
Publication Types:	Lecture Webcast

NLM Classification:	WF 200
NLM ID:	101655838
CIT Live ID:	15960
Permanent link:	https://videocast.nih.gov/watch=15960

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