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Tuning cell-surface receptor signaling through structure-based ligand engineering: Wnt/Frizzled and IgSF proteins

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Air date: Wednesday, November 5, 2014, 3:00:00 PM
Time displayed is Eastern Time, Washington DC Local
Views: Total views: 346, (123 Live, 223 On-demand)
Category: WALS - Wednesday Afternoon Lectures
Runtime: 00:56:28
Description: Wednesday Afternoon Lecture Series

Dr. Garcia's laboratory investigates the structural and functional aspects of cell-surface receptor recognition and activation in receptor-ligand systems with relevance to human health and disease. Structural information is exploited to understand the mechanisms of ligand recognition and signaling, as well as to inform engineering efforts to manipulate receptor signaling and generate therapeutics. The receptor systems studied derive principally from the immune system (TCR/MHC, cytokines), but additionally encompass several systems that are also important in neurobiology (Semaphorins) and development (Wnt, Notch). A major focus of the lab is on "shared" pleiotropic receptors, to understand the biophysical basis by which different cross-reactive ligands and receptors can elicit unique intracellular responses and functional outcomes. A recent effort in the lab has been to "deorphanize" cell surface receptors, the vast majority of which remain un-paired with a known ligand. In Dr. Garcia's seminar, he will discuss two new projects that focus on systems that exhibit properties of receptor-ligand pleiotropy: 1) Deconvoluting the cross-reactivity of Wnt interactions with Frizzled receptors, and 2) Identification of a new family of Immunoglobulin receptors and ligands that mediate cell-cell adhesion in neuronal structures.

For more information go to http://wals.od.nih.gov
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NLM Title: Tuning cell-surface receptor signaling through structure-based ligand engineering : Wnt/Frizzled and IgSF proteins / Christopher Garcia.
Author: Garcia, K Christopher.
National Institutes of Health (U.S.),
Publisher:
Abstract: (CIT): Dr. Garcia's laboratory investigates the structural and functional aspects of cell-surface receptor recognition and activation in receptor-ligand systems with relevance to human health and disease. Structural information is exploited to understand the mechanisms of ligand recognition and signaling, as well as to inform engineering efforts to manipulate receptor signaling and generate therapeutics. The receptor systems studied derive principally from the immune system (TCR/MHC, cytokines), but additionally encompass several systems that are also important in neurobiology (Semaphorins) and development (Wnt, Notch). A major focus of the lab is on "shared" pleiotropic receptors, to understand the biophysical basis by which different cross-reactive ligands and receptors can elicit unique intracellular responses and functional outcomes. A recent effort in the lab has been to "deorphanize" cell surface receptors, the vast majority of which remain un-paired with a known ligand. In Dr. Garcia's seminar, he will discuss two new projects that focus on systems that exhibit properties of receptor-ligand pleiotropy: 1) Deconvoluting the cross-reactivity of Wnt interactions with Frizzled receptors, and 2) Identification of a new family of Immunoglobulin receptors and ligands that mediate cell-cell adhesion in neuronal structures.
Subjects: Ligands
Receptors, Cell Surface--physiology
Signal Transduction
Publication Types: Lecture
Webcasts
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Caption Text: Download Caption File
NLM Classification: QU 55.7
NLM ID: 101647956
CIT Live ID: 15130
Permanent link: https://videocast.nih.gov/launch.asp?18715