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Understanding Circuit Plasticity in the Mammalian Olfactory System

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Air date: Friday, February 7, 2014, 12:00:00 PM
Time displayed is Eastern Time, Washington DC Local
Views: Total views: 217 (51 Live, 166 On-demand)
Category: NIH Director's Seminars
Runtime: 01:00:20
Description: Director's Seminar Series

In mammals, olfactory sensory neurons in the nose project their axons directly to the brain via the olfactory bulb where they organize to form a pair of glomerular maps that reflect odorant receptor identity. These maps are further connected through a set of central projections that specifically link iso-functional odor columns within the bulb to produce a second order intrabulbar map. We have shown that intrabulbar connections are established postnatally and undergo continuous refinement through an activity dependent process that has no critical period. Our work seeks to understand the basis of this ongoing network plasticity as we study the relationship between sensory-induced activity, neural regeneration and circuit remodeling in the olfactory bulb.
NLM Title: Understanding circuit plasticity in the mammalian olfactory system / Leonardo Belluscio.
Author: Belluscio, Leonardo.
National Institutes of Health (U.S.)
Publisher:
Abstract: (CIT): In mammals, olfactory sensory neurons in the nose project their axons directly to the brain via the olfactory bulb where they organize to form a pair of glomerular maps that reflect odorant receptor identity. These maps are further connected through a set of central projections that specifically link iso-functional odor columns within the bulb to produce a second order intrabulbar map. We have shown that intrabulbar connections are established postnatally and undergo continuous refinement through an activity dependent process that has no critical period. Our work seeks to understand the basis of this ongoing network plasticity as we study the relationship between sensory-induced activity, neural regeneration and circuit remodeling in the olfactory bulb.
Subjects: Mammals
Neuronal Plasticity--physiology
Olfactory Pathways--physiology
Smell--physiology
Publication Types: Lecture
Webcast
 
NLM Classification: WL 314
NLM ID: 101628108
CIT Live ID: 13700
Permanent link: https://videocast.nih.gov/watch=13700

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