NIH VideoCast - State-Dependent Inhibition in the Cortex

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State-Dependent Inhibition in the Cortex

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Air date:	Monday, January 27, 2014, 12:00:00 PM Time displayed is Eastern Time, Washington DC Local
Views:	Total views: 377 (37 Live, 340 On-demand)
Category:	Neuroscience
Runtime:	00:54:17
Closed captioning:	Check box to display CC outside of the video Note: You can drag the captioning window around and resize it
Description:	Neuroscience Seminar Series The cortex is made up of interconnected networks containing many different classes of neurons, whose roles in both normal brain activity and disease are poorly understood. Each neuron contributes to activity in the surrounding local network and receives a constant barrage of network synaptic input in return. The Cardin lab investigates this dynamic and bidirectional relationship between neuron and network at multiple levels, including cellular and synaptic mechanisms, network interactions, and behavior. They use a variety of techniques in rodent visual cortex, including intracellular and extracellular recordings in vivo, chronic recordings in awake behaving animals, and optogenetic manipulations of neural activity. A main goal of work in the laboratory is to identify and understand synaptic interactions between excitatory and inhibitory neurons during sensory processing. One ongoing focus is the cellular mechanisms of visual gain control and how gain modulation regulates visual perception. A second focus is to understand the flow of signals between cortical layers and how that process is affected by recruitment of local inhibitory interneurons. They are also interested in how interactions between different classes of neurons change in disease states such as epilepsy and schizophrenia.

NLM Title:	State-dependent inhibition in the cortex / Jessica Cardin.
Author:	Cardin, Jessica. National Institutes of Health (U.S.),
Publisher:
Abstract:	(CIT): The cortex is made up of interconnected networks containing many different classes of neurons, whose roles in both normal brain activity and disease are poorly understood. Each neuron contributes to activity in the surrounding local network and receives a constant barrage of network synaptic input in return. The Cardin lab investigates this dynamic and bidirectional relationship between neuron and network at multiple levels, including cellular and synaptic mechanisms, network interactions, and behavior. They use a variety of techniques in rodent visual cortex, including intracellular and extracellular recordings in vivo, chronic recordings in awake behaving animals, and optogenetic manipulations of neural activity. A main goal of work in the laboratory is to identify and understand synaptic interactions between excitatory and inhibitory neurons during sensory processing. One ongoing focus is the cellular mechanisms of visual gain control and how gain modulation regulates visual perception. A second focus is to understand the flow of signals between cortical layers and how that process is affected by recruitment of local inhibitory interneurons. They are also interested in how interactions between different classes of neurons change in disease states such as epilepsy and schizophrenia.
Subjects:	Mice--physiology Neural Inhibition--physiology Synaptic Transmission--physiology Visual Cortex--physiology Visual Perception--physiology
Publication Types:	Lecture Webcast

NLM Classification:	WL 102.8
NLM ID:	101624782
CIT Live ID:	13598
Permanent link:	https://videocast.nih.gov/watch=13598

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