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Combinatoriality, Signal Integration and Allostery: Determinants of Specific Transcriptional Regulation by the Glucocorticoid Receptor

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Air date: Wednesday, June 5, 2013, 3:00:00 PM
Time displayed is Eastern Time, Washington DC Local
Views: Total views: 183, (77 Live, 106 On-demand)
Category: WALS - Wednesday Afternoon Lectures
Runtime: 01:09:40
Description: Wednesday Afternoon Lecture Series

Specificity of metazoan transcription is determined combinatorially: different subsets of broadly expressed regulatory factors assemble as gene-, cell- and physiology-specific complexes at genomic response elements. Dr. Yamamoto’s laboratory studies suggest that key regulatory factors such as glucocorticoid receptor (GR) receive and integrate multiple signals as allosteric effectors, thus altering GR conformation and producing novel patterns of functional surfaces that nucleate distinct assemblies.
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NLM Title: Combinatoriality, signal integration, and allostery : determinants of specific transcriptional regulation by the glucocorticoid receptor / Keith R. Yamamoto.
Series: NIH Wednesday afternoon lecture
Author: Yamamoto, Keith R.
National Institutes of Health (U.S.),
Publisher:
Other Title(s): NIH Wednesday afternoon lecture
Abstract: (CIT): Wednesday Afternoon Lecture Series Specificity of metazoan transcription is determined combinatorially: different subsets of broadly expressed regulatory factors assemble as gene-, cell- and physiology-specific complexes at genomic response elements. Dr. Yamamoto"s laboratory studies suggest that key regulatory factors such as glucocorticoid receptor (GR) receive and integrate multiple signals as allosteric effectors, thus altering GR conformation and producing novel patterns of functional surfaces that nucleate distinct assemblies.
Subjects: Allosteric Regulation--genetics
Receptors, Glucocorticoid--genetics
Signal Transduction--genetics
Transcription, Genetic
Publication Types: Lectures
Webcasts
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NLM Classification: QU 475
NLM ID: 101611638
CIT Live ID: 12336
Permanent link: https://videocast.nih.gov/launch.asp?17986