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Towards Bioengineered Control of Cell Fate Post Transplantation

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Air date: Tuesday, February 7, 2012, 2:00:00 PM
Time displayed is Eastern Time, Washington DC Local
Views: Total views: 323, (29 Live, 294 On-demand)
Category: Stem Cell
Runtime: 01:03:31
Description: NIH CRM/SCIG Stem Cell Seminar Series:

Jeffrey Karp, PhD, Co-Director of Regenerative Therapeutics, Harvard Stem Cell Institute

Control of cell fate and its extracellular environment is critical for tissue regeneration and cell therapy. This talk will explore methods to enhance the engraftment of systemically infused stem cells through engineering the surface of cells to induce a robust rolling response. This approach is based on leukocytes ability to target tissues via specific interactions with the vascular endothelium. In addition, a novel strategy to engineer cells with an intracellular depot of phenotype altering agents will be described that can be used for programming cell fate via both intracrine-, paracrine-, and endocrine-like mechanisms. The talk will also examine the potential of cell surface sensors that can be used to detect signals within the cellular nano-environment with unprecedented spatial and temporal resolution and that should be useful for elucidating niche biology in vivo.
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NLM Title: Towards bioengineered control of cell fate post transplantation [electronic resource] / Jeffrey Karp.
Series: NIH NCRM/SCIG stem cell seminar series
Author: Karp, Jeffrey.
Publisher:
Other Title(s): NIH NCRM/SCIG stem cell seminar series
Abstract: (CIT): NIH CRM/SCIG Stem Cell Seminar Series: Jeffrey Karp, PhD, Co-Director of Regenerative Therapeutics, Harvard Stem Cell Institute Control of cell fate and its extracellular environment is critical for tissue regeneration and cell therapy. This talk will explore methods to enhance the engraftment of systemically infused stem cells through engineering the surface of cells to induce a robust rolling response. This approach is based on leukocytes ability to target tissues via specific interactions with the vascular endothelium. In addition, a novel strategy to engineer cells with an intracellular depot of phenotype altering agents will be described that can be used for programming cell fate via both intracrine-, paracrine-, and endocrine-like mechanisms. The talk will also examine the potential of cell surface sensors that can be used to detect signals within the cellular nano-environment with unprecedented spatial and temporal resolution and that should be useful for elucidating niche biology in vivo.
Subjects: Bioengineering--methods
Stem Cell Transplantation--methods
Publication Types: Lectures
Webcasts
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Caption Text: Download Caption File
NLM Classification: QU 325
NLM ID: 101578527
CIT Live ID: 10974
Permanent link: https://videocast.nih.gov/launch.asp?17096