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New Strategies for Decoding Genomes

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Air date: Wednesday, November 16, 2011, 3:00:00 PM
Time displayed is Eastern Time, Washington DC Local
Views: Total views: 636, (201 Live, 435 On-demand)
Category: WALS - Wednesday Afternoon Lectures
Runtime: 01:02:14
Description: The ability to sequence genomes has far outstripped approaches for deciphering the information they encode. We have developed a suite of techniques based on ribosome profiling (deep sequencing of ribosome protected fragments) that dramatically expand our ability to follow translation in vivo. I will present recent applications of our ribosome profiling approach including the following: (1) Development of ribosome profiling protocols for a wide variety of eukaryotic and prokaryotic organisms. (2) Uses of ribosome profiling to globally monitor when chaperones, targeting factors or processing enzymes engage nascent chains. (3) Deciphering the driving force and biological consequences underlying the choice of synonymous codons.

The NIH Wednesday Afternoon Lecture Series includes weekly scientific talks by some of the top researchers in the biomedical sciences worldwide.

For more information, visit:
The NIH Director's Wednesday Afternoon Lecture Series
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NLM Title: New strategies for decoding genomes [electronic resource] / Jonathan Weissman.
Series: NIH Wednesday afternoon lecture
Author: Weissman, Jonathan.
Publisher:
Other Title(s): NIH Wednesday afternoon lecture
Abstract: (CIT): The ability to sequence genomes has far outstripped approaches for deciphering the information they encode. We have developed a suite of techniques based on ribosome profiling (deep sequencing of ribosome protected fragments) that dramatically expand our ability to follow translation in vivo. I will present recent applications of our ribosome profiling approach including the following: (1) Development of ribosome profiling protocols for a wide variety of eukaryotic and prokaryotic organisms. (2) Uses of ribosome profiling to globally monitor when chaperones, targeting factors or processing enzymes engage nascent chains. (3) Deciphering the driving force and biological consequences underlying the choice of synonymous codons. The NIH Wednesday Afternoon Lecture Series includes weekly scientific talks by some of the top researchers in the biomedical sciences worldwide. For more information, visit: The NIH Director's Wednesday Afternoon Lecture Series.
Subjects: Genome--genetics
Genomics--methods
Sequence Analysis--methods
Publication Types: Lectures
Webcasts
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Caption Text: Download Caption File
NLM Classification: QU 470
NLM ID: 101574485
CIT Live ID: 10507
Permanent link: https://videocast.nih.gov/launch.asp?16973

 

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