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Regulation of limb development:linking early patterning, growth and morphogenesis

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Air date: Friday, June 24, 2011, 12:00:00 PM
Time displayed is Eastern Time, Washington DC Local
Views: Total views: 177 * This only includes stats from October 2011 and forward.
Category: NIH Director's Seminars
Runtime: 00:56:09
Description: Director's Seminar Series

Susan Mackem received her PhD from the University of Chicago as an MSTP trainee and completed her MD at The Johns Hopkins University School of Medicine in 1984. After residency training in Pathologic Anatomy, she continued her training as a cancer expert in the Laboratory of Pathology, NCI. In 1995 she became a tenure track investigator and in 2008, she joined the Cancer and Developmental Biology Laboratory, NCI, where she is currently a senior investigator.

Dr. Mackem's lab studies limb development as a paradigm to understand how signaling networks orchestrate the formation of a complex tissue. The lab uses combined genetic, genomic, and biochemical approaches to study transcription factors and signaling cascades that regulate the formation and correct pattern of the different digit types (from thumb to pinky) and unravel the regulatory hierarchy between early patterning and digit morphogenesis. A major focus has been the role of Sonic Hedgehog and its signaling targets. Recently, Dr. Mackem's group showed that Sonic hedgehog is required only very transiently to specify digit pattern but for an extended period to promote growth and determine digit numbers. Their results challenge current paradigms on Shh function as a temporally integrated morphogen. The roles of the Gli3 hedgehog-effector and 5'HoxD homeobox gene targets extend from early to late stages of limb development, and the lab has found that they cooperate in the late morphogenetic realization of patterning cues by regulating the segmentation of digits during joint formation.
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NLM Title: Regulation of limb development : inking early patterning, growth, and morphogenesis / Susan Mackem.
Author: Mackem, Susan.
National Institutes of Health (U.S.)
Publisher:
Abstract: (CIT): Director's Seminar Series Susan Mackem received her PhD from the University of Chicago as an MSTP trainee and completed her MD at The Johns Hopkins University School of Medicine in 1984. After residency training in Pathologic Anatomy, she continued her training as a cancer expert in the Laboratory of Pathology, NCI. In 1995 she became a tenure track investigator and in 2008, she joined the Cancer and Developmental Biology Laboratory, NCI, where she is currently a senior investigator. Dr. Mackem's lab studies limb development as a paradigm to understand how signaling networks orchestrate the formation of a complex tissue. The lab uses combined genetic, genomic, and biochemical approaches to study transcription factors and signaling cascades that regulate the formation and correct pattern of the different digit types (from thumb to pinky) and unravel the regulatory hierarchy between early patterning and digit morphogenesis. A major focus has been the role of Sonic Hedgehog and its signaling targets. Recently, Dr. Mackem's group showed that Sonic hedgehog is required only very transiently to specify digit pattern but for an extended period to promote growth and determine digit numbers. Their results challenge current paradigms on Shh function as a temporally integrated morphogen. The roles of the Gli3 hedgehog-effector and 5'HoxD homeobox gene targets extend from early to late stages of limb development, and the lab has found that they cooperate in the late morphogenetic realization of patterning cues by regulating the segmentation of digits during joint formation.
Subjects: Extremities--growth & development
Morphogenesis--genetics
Publication Types: Lecture
Webcasts
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Caption Text: Download Caption File
NLM Classification: WE 800
NLM ID: 101565237
CIT Live ID: 10348
Permanent link: https://videocast.nih.gov/launch.asp?16741