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Translational Neuroscience for Schizophrenia

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Air date: Monday, June 13, 2011, 12:00:00 PM
Time displayed is Eastern Time, Washington DC Local
Views: Total views: 418 * This only includes stats from October 2011 and forward.
Category: Neuroscience
Runtime: 01:05:56
Description: Neuroscience Seminar Series

Dr. Akira Sawa is the Director of the Program in Molecular Psychiatry and Professor, Department of Psychiatry and Behavioral Sciences and Department of Neuroscience Graduate Program in Cellular and Molecular Medicine. He received his MD and PhD from the University of Tokyo, Japan in 1990 and 1994, respectively. From there he moved to Johns Hopkins University to do postdoctoral work with Dr. Solomon Snyder, and he subsequently became part of the Hopkins faculty.

The research in his laboratory is directed towards understanding the pathogenesis of neuropsychiatric illnesses, especially schizophrenia and neurodegenerative disorders, at the molecular level. In a bottom-up approach, the lab focuses on molecular targets, such as disease risk gene products and/or key cellular mediators, testing how such molecular targets are functionally related with each other in cells and neuronal networks of animal models, and how they contribute to development of disease phenotypes during a time course. A recent study indicates that schizophrenia-associated alteration of Disrupted-In-Schizophrenia (DISC1) leads to disturbance of proper development in cerebral cortex. In a top-down approach, clinical information and patient tissues are analyzed towards identifying novel molecular targets or new biomarkers of disease. Biopsy of olfactory epithelium from schizophrenics is used to characterize neuronal cells, and lymphoblastoid cells collected from peripheral blood are analyzed with microarray and proteomic approaches to identify novel and useful biomarkers for schizophrenia.

For more information, visit: http://neuroseries.info.nih.gov
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NLM Title: Translational neuroscience for schizophrenia [electronic resource] / Akira Sawa.
Author: Sawa, Akira.
Publisher:
Abstract: (CIT): Neuroscience Seminar Series Dr. Akira Sawa is the Director of the Program in Molecular Psychiatry and Professor, Department of Psychiatry and Behavioral Sciences and Department of Neuroscience Graduate Program in Cellular and Molecular Medicine. He received his MD and PhD from the University of Tokyo, Japan in 1990 and 1994, respectively. From there he moved to Johns Hopkins University to do postdoctoral work with Dr. Solomon Snyder, and he subsequently became part of the Hopkins faculty. The research in his laboratory is directed towards understanding the pathogenesis of neuropsychiatric illnesses, especially schizophrenia and neurodegenerative disorders, at the molecular level. In a bottom-up approach, the lab focuses on molecular targets, such as disease risk gene products and/or key cellular mediators, testing how such molecular targets are functionally related with each other in cells and neuronal networks of animal models, and how they contribute to development of disease phenotypes during a time course. A recent study indicates that schizophrenia-associated alteration of Disrupted-In-Schizophrenia (DISC1) leads to disturbance of proper development in cerebral cortex. In a top-down approach, clinical information and patient tissues are analyzed towards identifying novel molecular targets or new biomarkers of disease. Biopsy of olfactory epithelium from schizophrenics is used to characterize neuronal cells, and lymphoblastoid cells collected from peripheral blood are analyzed with microarray and proteomic approaches to identify novel and useful biomarkers for schizophrenia.
Subjects: Biomarkers
Nerve Tissue Proteins
Schizophrenia--pathology
Translational Medical Research
Publication Types: Lectures
Webcasts
Download: To download this event, select one of the available bitrates:
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NLM Classification: WM 203
NLM ID: 101565222
CIT Live ID: 10295
Permanent link: https://videocast.nih.gov/launch.asp?16706

 

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