NIH VideoCast - Genetic Studies of Telencephalon Development

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Genetic Studies of Telencephalon Development

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Air date:	Monday, April 4, 2011, 12:00:00 PM Time displayed is Eastern Time, Washington DC Local
Views:	Total views: 206 * This only includes stats from October 2011 and forward.
Category:	Neuroscience
Runtime:	00:56:44
Closed captioning:	Check box to display CC outside of the video Note: You can drag the captioning window around and resize it
Description:	Neuroscience Seminar Series The goal of Dr. Rubenstein’s research is to elucidate fundamental mechanisms that regulate development of the forebrain and in parallel, whether disruption of these mechanisms underlie human disorders, such as autism, schizophrenia, mental retardation, epilepsy and craniofacial disorders. Investigations include studies on secreted factors, such as Fgf8 and Fgf17, that function in regionalization of the neural plate and cerebral cortex. They have shown that Fgf17 mutant mice have hypoplasia of their anterior cingulate gyrus, and behavioral deficits in social interactions. Ongoing studies also focus on defining transcription factors that control CNS development, including Nkx genes (specifying ventral neural progenitors) and Dlx1 and 2 (involved in differentiation of GABAergic neurons). In addition, Dr. Rubenstein has been involved in investigations on tangential migration in the CNS. Studying the migration of GABAergic neurons from the subcortical telencephalon into the cerebral cortex, both factors controlling movement of the cells as well as integration of the cells once they reach their destination. Finally, the lab has a longstanding clinical interest in Autism, with work focused on sequencing of candidate genes and functional analyses of mutant alleles. For more information, visit: http://neuroseries.info.nih.gov

NLM Title:	Genetic studies of telencephalon development / John Rubenstein.
Author:	Rubenstein, John L R. National Institutes of Health (U.S.)
Publisher:
Abstract:	(CIT): The goal of Dr. Rubenstein's research is to elucidate fundamental mechanisms that regulate development of the forebrain and in parallel, whether disruption of these mechanisms underlie human disorders, such as autism, schizophrenia, mental retardation, epilepsy and craniofacial disorders. Investigations include studies on secreted factors, such as Fgf8 and Fgf17, that function in regionalization of the neural plate and cerebral cortex. They have shown that Fgf17 mutant mice have hypoplasia of their anterior cingulate gyrus, and behavioral deficits in social interactions. Ongoing studies also focus on defining transcription factors that control CNS development, including Nkx genes (specifying ventral neural progenitors) and Dlx1 and 2 (involved in differentiation of GABAergic neurons). In addition, Dr. Rubenstein has been involved in investigations on tangential migration in the CNS. Studying the migration of GABAergic neurons from the subcortical telencephalon into the cerebral cortex, both factors controlling movement of the cells as well as integration of the cells once they reach their destination. Finally, the lab has a longstanding clinical interest in Autism, with work focused on sequencing of candidate genes and functional analyses of mutant alleles.
Subjects:	Mice Models, Animal Telencephalon--growth & development
Publication Types:	Lecture Webcast

NLM Classification:	WL 307
NLM ID:	101559825
CIT Live ID:	10130
Permanent link:	https://videocast.nih.gov/watch=10130

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