Skip Navigation


CIT can broadcast your seminar, conference or meeting live to a world-wide audience over the Internet as a real-time streaming video. The event can be recorded and made available for viewers to watch at their convenience as an on-demand video or a downloadable podcast. CIT can also broadcast NIH-only or HHS-only content.

Neural Plasticity and Diversity in the Adult Mammalian Brain

Loading video...

 
   
Air date: Thursday, March 17, 2011, 3:00:00 PM
Time displayed is Eastern Time, Washington DC Local
Views: Total views: 187 * This only includes stats from October 2011 and forward.
Category: WALS - Wednesday Afternoon Lectures
Runtime: 01:11:42
Description: The first part of the talk will focus on evidence supporting the birth and maturation of new neurons in the adult dentate gyrus of the hippocampus in the mammalian brain. The mechanism by which the cells integrate and become functional will be discussed. In addition, the potential functional significance for adult neurogenesis in the context of the normal function of the hippocampus will be discussed. In the second part of the talk I will focus on the recent finding that LINE-1 (Long Interspersed Nucleotide Elements-1 or L1) retroelements are active in somatic neuronal progenitor cells (NPCs) providing an additional mechanism for neuronal diversification. Together with their mutated relatives, retroelement sequences constitute 45% of the mammalian genome with L1 elements alone representing 20%.

The fact that L1 can retrotranspose in a defined window of neuronal differentiation, changing the genetic information in single neurons in an arbitrary fashion, allows the brain to develop in distinctly different ways. This characteristic of variety and flexibility may contribute to the uniqueness of an individual brain. However, the molecular mechanism that regulates L1 expression in NPCs is not completely understood. L1s are likely silenced in neural stem cells due to Sox2-mediated transcription repression. Down-regulation of Sox2 accompanies chromatin modifications, such as DNA de-methylation and histone acetylation, which in turn may trigger neuronal differentiation. The characterization of somatic neuronal diversification will not only be relevant for the understanding of brain complexity and neuronal organization in mammals, but may also shed light on the differences in cognitive abilities.

The NIH Director's Wednesday Afternoon Lecture Series includes weekly scientific talks by some of the top researchers in the biomedical sciences worldwide.
Debug: Show Debug
NLM Title: Neural plasticity and diversity in the adult mammalian brain [electronic resource] / Fred Gage.
Series: NIH Wednesday afternoon lecture series
Author: Gage, F.
National Institutes of Health (U.S.)
Publisher:
Other Title(s): NIH Wednesday afternoon lecture series
Abstract: (CIT): The first part of the talk will focus on evidence supporting the birth and maturation of new neurons in the adult dentate gyrus of the hippocampus in the mammalian brain. The mechanism by which the cells integrate and become functional will be discussed. In addition, the potential functional significance for adult neurogenesis in the context of the normal function of the hippocampus will be discussed. In the second part of the talk I will focus on the recent finding that LINE-1 (Long Interspersed Nucleotide Elements-1 or L1) retroelements are active in somatic neuronal progenitor cells (NPCs) providing an additional mechanism for neuronal diversification. Together with their mutated relatives, retroelement sequences constitute 45% of the mammalian genome with L1 elements alone representing 20%. The fact that L1 can retrotranspose in a defined window of neuronal differentiation, changing the genetic information in single neurons in an arbitrary fashion, allows the brain to develop in distinctly different ways. This characteristic of variety and flexibility may contribute to the uniqueness of an individual brain. However, the molecular mechanism that regulates L1 expression in NPCs is not completely understood. L1s are likely silenced in neural stem cells due to Sox2-mediated transcription repression. Down-regulation of Sox2 accompanies chromatin modifications, such as DNA de-methylation and histone acetylation, which in turn may trigger neuronal differentiation. The characterization of somatic neuronal diversification will not only be relevant for the understanding of brain complexity and neuronal organization in mammals, but may also shed light on the differences in cognitive abilities.
Subjects: Hippocampus
Long Interspersed Nucleotide Elements
Neural Stem Cells
Neuronal Plasticity
Publication Types: Lectures
Webcasts
Download: To download this event, select one of the available bitrates:
[256k]  [512k]    How to download a Videocast
Caption Text: Download Caption File
NLM Classification: WL 102
NLM ID: 101559805
CIT Live ID: 10076
Permanent link: https://videocast.nih.gov/launch.asp?16539

 

Podcast information
Audio Podcasts   Video Podcasts
  Description Runtime     Description Runtime
Listen to the podcast Audio Podcast 1:11:42   Watch the podcast Video Podcast 1:11:42