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Dr. Rauscher's research at Wistar focuses on the molecular genetics of cancer.
In particular, he is interested in the structure-function aspects of tumor suppressor and oncogene proteins, mechanisms of transcriptional regulation, transcriptional control of cellular differentiation programs and organogenesis.
Several years ago, he and his research team described the function of the WT1 gene that, when mutated, causes Wilms' Tumor. More recently, Dr. Rauscher and his team discovered BAP1, a gene encoding an enzyme that helps regulate levels
of BRCA1 and is involved in the development of breast and lung cancers.