NIH VideoCast - Mapping Gene Regulatory Pathways by Assembly of Physical and Genetic Interactions

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Mapping Gene Regulatory Pathways by Assembly of Physical and Genetic Interactions

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Air date:	Tuesday, February 19, 2008, 2:00:00 PM Time displayed is Eastern Time, Washington DC Local
Views:	Total views: 150 * This only includes stats from October 2011 and forward.
Category:	Special
Runtime:	01:02:36
Closed captioning:	Check box to display CC outside of the video Note: You can drag the captioning window around and resize it
Description:	Physical and genetic mapping data have become as important to Network Biology as they were to the Human Genome Project. Physical interaction maps are being constructed through systematic measurements of protein-protein, protein-DNA, and protein-small molecule interactions. Genetic interaction maps are being generated by large-scale screening of synthetic-lethals and epistasis, by multipoint gene association studies, and by mapping the effects of natural and prescribed genetic variations on gene expression. We are working on ways of integrating physical and genetic interaction maps to assemble models of gene regulatory pathways. These efforts face several challenges, including: increasing the coverage of each type of network; establishing methods to assemble individual interaction measurements into contiguous pathway models; and annotating these pathways with detailed functional information. Efforts in each of these areas will be described. Using integrative tools, we are constructing network models to explain the physiological response of yeast to DNA damaging agents. http://www.nih.gov/sigs/sysbio

NLM Title:	Mapping gene regulatory pathways by assembly of physical and genetic interactions / Trey Ideker.
Author:	Ideker, Trey. National Institutes of Health (U.S.). Systems Biology Special Interest Group.
Publisher:
Abstract:	(CIT): Physical and genetic mapping data have become as important to Network Biology as they were to the Human Genome Project. Physical interaction maps are being constructed through systematic measurements of protein-protein, protein-DNA, and protein-small molecule interactions. Genetic interaction maps are being generated by large-scale screening of synthetic-lethals and epistasis, by multipoint gene association studies, and by mapping the effects of natural and prescribed genetic variations on gene expression. We are working on ways of integrating physical and genetic interaction maps to assemble models of gene regulatory pathways. These efforts face several challenges, including: increasing the coverage of each type of network; establishing methods to assemble individual interaction measurements into contiguous pathway models; and annotating these pathways with detailed functional information. Efforts in each of these areas will be described. Using integrative tools, we are constructing network models to explain the physiological response of yeast to DNA damaging agents.
Subjects:	Chromosome Mapping Computational Biology--methods Gene Expression Regulation Gene Regulatory Networks--genetics
Publication Types:	Lecture Webcast
NLM Classification:	QU 450
NLM ID:	101468731
CIT Live ID:	6595
Permanent link:	https://videocast.nih.gov/watch=6595

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