NIH VideoCast - Bidirectional Signal Transmission in Integrins

Skip Navigation

Bidirectional Signal Transmission in Integrins

Loading... Loading video...

Air date:	Wednesday, February 6, 2008, 4:15:00 PM Time displayed is Eastern Time, Washington DC Local
Views:	Total views: 154 * This only includes stats from October 2011 and forward.
Category:	Immunology
Runtime:	00:59:42
Closed captioning:	Check box to display CC outside of the video Note: You can drag the captioning window around and resize it
Description:	Tim received his Ph.D. in biochemistry and molecular biology from Harvard with Jack Strominger and his postdoctoral training from MRC Laboratory of Molecular Biology with Cesar Milstein. He then rose through the ranks from assistant professor in 1977 to full professor in 1989 at Harvard Medical School. The Springer lab has discovered and worked on families of adhesion and chemoattractant receptors that regulate specific cellular interactions, localization, migration, and differentiation of cells of the immune system. He is a pioneer in the biochemical characterization of the cell adhesion molecules such as integrins, selectins and their ligands. His lab demonstrated the three-step model of leukocyte localization at inflammatory sites mediated by selectins, G protein-coupled receptors and integrins. He and colleagues presented the first evidence that the function of the lymphocyte function-associated antigen LFA-1 was regulated by TCR through what became known as “inside-out signaling”, suggesting a conformational regulation mechanism. More recently, Tim has been seeking to understand, at the atomic level in three dimensions, such conformational changes of the adhesion molecules and the resulting signal transmission events across the membrane bilayer. The Springer lab found inherited defects of integrins in leukocyte adhesion deficiency, ICAM-1 as the cellular receptor for rhinovirus, and SDF-1 as the natural ligand for the HIV coreceptor CXCR4. The discoveries of LFA-1 and LFA-3 resulted in two new drugs for the treatment of severe to moderate plaque psoriasis: efalizumab (LFA-1 antibody by Genentech) and elefacept (LFA-3-Fc fusion protein by Biogen). Tim’s distinguished career has been recognized by awards from the American Heart Association, Cancer Research Institute, Society for Leukocyte Biology, and Royal Society of Medicine from United Kingdom. He was elected to the National Academy of Science in 1996 and to the American Academy of Arts and Sciences in 2001. In 2004, he was co-recipient of the prestigious Crafoord Prize by the Royal Swedish Academy of Sciences. The Immunology Interest Group (IIG) organizes activities designed to promote information exchange and interactions among NIH scientists interested in the field of immunology, broadly defined. Interactions are facilitated via weekly meetings on current topics as well as an annual Immunology Retreat. For more information, visit The Immunology Interest Group

NLM Title:	Bidirectional signal transmission in integrins / Timothy Springer.
Author:	Springer, Timothy A. National Institutes of Health (U.S.)
Publisher:
Abstract:	(CIT): Tim has been seeking to understand, at the atomic level in three dimensions, such conformational changes of the adhesion molecules and the resulting signal transmission events across the membrane bilayer. The Springer lab found inherited defects of integrins in leukocyte adhesion deficiency, ICAM-1 as the cellular receptor for rhinovirus, and SDF-1 as the natural ligand for the HIV coreceptor CXCR4.
Subjects:	Cell Movement Integrins Signal Transduction
Publication Types:	Webcast
NLM Classification:	QW 570
NLM ID:	101469019
CIT Live ID:	6140
Permanent link:	https://videocast.nih.gov/watch=6140

Related Videos...