Phosphoinositide 3-Kinase Pathway and Human Disease

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Air date:	Wednesday, February 9, 2005, 3:00:00 PM Time displayed is Eastern Time, Washington DC Local
Views:	Total views: 114 * This only includes stats from October 2011 and forward.
Category:	WALS - Wednesday Afternoon Lectures
Runtime:	01:11:16
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Description:	Phosphoinositide 3-kinase (PI3K) is activated by a host of hormones and growth factors and produces membrane bound lipid second messengers that are implicated in complex cellular events such as cell survival, cell growth, cell cycle entry and chemotaxis, based on ex-vivo experiments. We have used a variety of approaches to map protein kinase pathways upstream and downstream of PI3K. In addition, we have manipulated genes in the mouse to assess the role of PI3K and downstream responses in normal development, in insulin signaling and in cancers. These studies have revealed a tightly regulated and highly conserved signaling network, perturbations of which can result in a wide variety of diseases, including cancers, tuberous sclerosis and type 2 diabetes. For more information, visit http://www.fas.harvard.edu/%7Ebiophys/Lewis_Cantley.htm WALS

Author:	Lewis Cantley, Ph.D., Harvard Institutes of Medicine
CIT Live ID:	3441
Permanent link:	https://videocast.nih.gov/watch=3441

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