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Proteomic Tools for Studying Mitochondrial Dysfunction and Age-Related Diseases

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Air date: Friday, November 14, 2003, 10:00:00 AM
Time displayed is Eastern Time, Washington DC Local
Views: Total views: 30 * This only includes stats from October 2011 and forward.
Category: Proteomics
Runtime: 01:12:26
Description: The evidence linking mitochondria to normal aging and age-related disorders has increased in recent years. Therefore, it has become increasingly apparent that mitochondrial function and dysfunction need to be probed if these pathologies are to be understood at the cellular level. For example, mitochondrial protein expression profiling of disease tissue from patients with Alzheimer's disease, Parkinson's disease and other mitochondria-linked diseases will be essential to reach a more complete understanding of the role of mitochondria in the progression or etiology of these disorders. Differential patterns in protein expression or posttranslational modifications may reveal novel molecular targets for drug discovery and diagnostic protein markers that could serve as biomarkers of disease and disease progression.

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Proteome Interest Group
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NLM Title: Proteomic tools for studying mitochondrial dysfunction and age-related diseases [electronic resource] / Bradford W. Gibson.
Author: Gibson, Bradford W.
National Institutes of Health (U.S.)
Publisher:
Abstract: (CIT): The evidence linking mitochondria to normal aging and age-related disorders has increased in recent years. Therefore, it has become increasingly apparent that mitochondrial function and dysfunction need to be probed if these pathologies are to be understood at the cellular level. For example, mitochondrial protein expression profiling of disease tissue from patients with Alzheimer's disease, Parkinson's disease and other mitochondria-linked diseases will be essential to reach a more complete understanding of the role of mitochondria in the progression or etiology of these disorders. Differential patterns in protein expression or posttranslational modifications may reveal novel molecular targets for drug discovery and diagnostic protein markers that could serve as biomarkers of disease and disease progression. For more information, visit Proteome Interest Group.
Subjects: Aging
Mitochondrial Diseases
Mitochondrial Proteins
Proteomics
Publication Types: Lectures
Webcasts
Rights: This is a work of the United States Government. No copyright exists on this material. It may be disseminated freely.
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NLM Classification: QU 350
NLM ID: 101268287
CIT Live ID: 2919
Permanent link: https://videocast.nih.gov/launch.asp?11628