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Kinyoun Lecture - Treating Auto-inflammatory Diseases with Interleukin-1 Beta Blockade

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Air date: Thursday, November 18, 2010, 3:00:00 PM
Time displayed is Eastern Time, Washington DC Local
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Category: Joseph J. Kinyoun - Infection and Immunity
Runtime: 01:03:35
Description: 2010 Kinyoun Lecture

Dr. Charles Dinarello, who purified and cloned interleukin-1beta (IL 1beta), once known as the fever molecule, will deliver the 2010 Kinyoun Lecture on Thursday, Nov. 18, at 3 p.m. in Lipsett Amphitheater, Bldg. 10. Dinarello is professor of medicine and immunology at the University of Colorado School of Medicine and a former investigator in NIAID’s Laboratory of Clinical Investigation.

Dinarello’s talk, titled “Treating Auto-inflammatory Diseases with Interleukin-1 beta Blockade,” will include an overview of autoinflammatory diseases, such as type 2 diabetes mellitus and gout, and describe differences between these and autoimmune diseases. He also will discuss treatment of inflammatory diseases using IL-1beta blocking agents.

Considered one of the founding fathers of cytokine biology, Dinarello’s work with IL-1 helped to establish the significance of cytokines in inflammatory diseases. His recognition of the importance of IL-1 in inflammatory diseases led to the development of therapies that inhibit IL-1 and thereby reduce disease severity. These therapies include those based on the IL-1 receptor antagonist, monoclonal antibodies and soluble receptors.
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NLM Title: Treating auto-inflammatory diseases with interleukin-1 beta blockade [electronic resource] / Charles A. Dinarello.
Series: Kinyoun lecture
Author: Dinarello, Charles A.
National Institutes of Health (U.S.)
Publisher:
Other Title(s): Kinyoun lecture
Abstract: (CIT): 2010 Kinyoun Lecture Dr. Charles Dinarello, who purified and cloned interleukin-1beta (IL 1beta), once known as the fever molecule, will deliver the 2010 Kinyoun Lecture on Thursday, Nov. 18, at 3 p.m. in Lipsett Amphitheater, Bldg. 10. Dinarello is professor of medicine and immunology at the University of Colorado School of Medicine and a former investigator in NIAID"s Laboratory of Clinical Investigation. Dinarello"s talk, titled "Treating Auto-inflammatory Diseases with Interleukin-1 beta Blockade," will include an overview of autoinflammatory diseases, such as type 2 diabetes mellitus and gout, and describe differences between these and autoimmune diseases. He also will discuss treatment of inflammatory diseases using IL-1beta blocking agents. Considered one of the founding fathers of cytokine biology, Dinarello"s work with IL-1 helped to establish the significance of cytokines in inflammatory diseases. His recognition of the importance of IL-1 in inflammatory diseases led to the development of therapies that inhibit IL-1 and thereby reduce disease severity. These therapies include those based on the IL-1 receptor antagonist, monoclonal antibodies and soluble receptors.
Subjects: Inflammation--drug therapy
Interleukin-1beta--immunology
Receptors, Interleukin-1--antagonists & inhibitors
Publication Types: Lectures
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Download: To download this event, select one of the available bitrates:
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NLM Classification: QW 568
NLM ID: 101549265
CIT Live ID: 9579
Permanent link: http://videocast.nih.gov/launch.asp?16281

 

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