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Dr. Charles Dinarello, who purified and cloned interleukin-1beta (IL 1beta), once known as the fever molecule, will deliver the 2010 Kinyoun Lecture on Thursday, Nov. 18, at 3 p.m. in Lipsett Amphitheater, Bldg. 10. Dinarello is professor of medicine and immunology at the University of Colorado School of Medicine and a former investigator in NIAID’s Laboratory of Clinical Investigation.
Dinarello’s talk, titled “Treating Auto-inflammatory Diseases with Interleukin-1 beta Blockade,” will include an overview of autoinflammatory diseases, such as type 2 diabetes mellitus and gout, and describe differences between these and autoimmune diseases. He also will discuss treatment of inflammatory diseases using IL-1beta blocking agents.
Considered one of the founding fathers of cytokine biology, Dinarello’s work with IL-1 helped to establish the significance of cytokines in inflammatory diseases. His recognition of the importance of IL-1 in inflammatory diseases led to the development of therapies that inhibit IL-1 and thereby reduce disease severity. These therapies include those based on the IL-1 receptor antagonist, monoclonal antibodies and soluble receptors.
Runtime:
01:03:35
NLM Title:
Treating auto-inflammatory diseases with interleukin-1 beta blockade [electronic resource] / Charles A. Dinarello.
Series:
Kinyoun lecture
Author:
Dinarello, Charles A. National Institutes of Health (U.S.)
Publisher:
[Bethesda, Md. : National Institutes of Health, 2010]
Other Title(s):
Kinyoun lecture
Abstract:
(CIT): 2010 Kinyoun Lecture Dr. Charles Dinarello, who purified and cloned interleukin-1beta (IL 1beta), once known as the fever molecule, will deliver the 2010 Kinyoun Lecture on Thursday, Nov. 18, at 3 p.m. in Lipsett Amphitheater, Bldg. 10. Dinarello is professor of medicine and immunology at the University of Colorado School of Medicine and a former investigator in NIAID"s Laboratory of Clinical Investigation. Dinarello"s talk, titled "Treating Auto-inflammatory Diseases with Interleukin-1 beta Blockade," will include an overview of autoinflammatory diseases, such as type 2 diabetes mellitus and gout, and describe differences between these and autoimmune diseases. He also will discuss treatment of inflammatory diseases using IL-1beta blocking agents. Considered one of the founding fathers of cytokine biology, Dinarello"s work with IL-1 helped to establish the significance of cytokines in inflammatory diseases. His recognition of the importance of IL-1 in inflammatory diseases led to the development of therapies that inhibit IL-1 and thereby reduce disease severity. These therapies include those based on the IL-1 receptor antagonist, monoclonal antibodies and soluble receptors.
