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Mesothelioma: Clinical Frustration Mandating Scientific Inquiry (NIH-Only)

Air date: Tuesday, May 5, 2009, 8:00:00 AM
Time displayed is Eastern Time, Washington DC Local
Description: Dr. Pass received his B.A. from Johns Hopkins University and his M.D. from Duke University. He completed his surgical residency at Duke and University of Mississippi. He completed his residency in Cardiothoracic Surgery at the Medical University of South Carolina. Dr. Pass also completed a fellowship in Thoracic Oncology at the National Cancer Institute (NCI) at NIH.

Dr. Pass joined NYU Langone Medical Center in 2005 as Professor of Cardiothoracic Surgery and Surgery, and was the first Division Chief of Thoracic Surgery/ Thoracic Oncology at NYU School of Medicine. His previous positions include Chief, Thoracic Oncology at the Karmanos Cancer Institute, Detroit, affiliated with Wayne State University, and he was the Head of the Thoracic Oncology Section at NCI from 1986 to 1996. He is an internationally recognized expert in lung cancer and mesothelioma and has maintained extramural funding from the Department of Veterans Affairs and the National Cancer Institute for his translational laboratory since 1998. He is presently funded by the Early Detection Research Network for the Mesothelioma Biomarker Discovery Laboratory, the Center for Disease Control for the Mesothelioma Virtual Tissue Bank, and by the NCI for the Program Project entitled Pathogenesis of Mesothelioma. Dr. Pass has published more than 320 manuscripts in peer-reviewed journals, including The New England Journal of Medicine regarding the discovery of osteopontin as a possible early detection biomarker for mesothelioma. He is the lead editor on all four editions of the reference text Lung Cancer: Principles and Practice. He is co-editor of both editions of Surgery: Basic Science and Clinical Evidence, and Oncology: An Evidence Based Approach, and has also edited Malignant Mesothelioma: Advances in Pathogenesis, Diagnosis, and Translational Therapies and 100 Questions & Answers about Mesothelioma. He is Associate Editor for the Journal of Thoracic Oncology, Surgical Editor for Clinical Lung Cancer, and a member of the editorial board for Clinical Cancer Research. He is presently on the Board of Directors for the International Association for the Study of Lung Cancer, the International Mesothelioma Interest Group, and the Lung Cancer Alliance. He is the 2008 recipient of the Landon Research Award presented by AACR and of the Pioneer Award presented by the Mesothelioma Applied Research Foundation.

SELECTED REFERENCES:
1. Flores RM, Pass HI, Seshan VE, Dycoco J, Zakowski M, Carbone M, et al. Extrapleural pneumonectomy versus pleurectomy/decortication in the surgical management of malignant pleural mesothelioma: results in 663 patients. J Thorac Cardiovasc Surg 2008 Mar;135(3):620-6, 626.
2. Kaufman AJ, Pass HI. Current concepts in malignant pleural mesothelioma. Expert Rev Anticancer Ther 2008 Feb;8(2):293-303.
3. Pass HI, Lott D, Lonardo F, Harbut M, Liu Z, Tang N, et al. Asbestos exposure, pleural mesothelioma, and serum osteopontin levels. N Engl J Med 2005 Oct 13;353(15):1564-73

NCI’s Center for Cancer Research (CCR) Grand Rounds is a weekly lecture series addressing current research in clinical and molecular oncology. Speakers are leading national and international researchers and clinicians proposed by members of the CCR Grand Rounds Planning Committee and others within the CCR community and approved by the CCR Office of the Director. Lectures occur every Tuesday from 8:00 to 9:00 a.m. in Lipsett Amphitheater in the Clinical Center building on the NIH campus September through July with exceptions around holidays and major cancer meetings. The lecture schedule is posted on various calendars of events, including at the following link:
http://www.bethesdatrials.cancer.gov/health-care-professionals/grand-rounds.aspx
Author: Harvey I. Pass, M.D.
Runtime: 1 hour