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Yvonne Jones is co-Head of STRUBI and Deputy Head of the NDM. Her own research group is focused on the structural biology of extracellular recognition and signaling complexes. The group's core techniques include protein crystallography and cryo electron microscopy, which are used to generate high resolution structural information. Importantly, studies using these techniques are integrated with advanced light microscopy and cryo electron tomography, as well as cell-based functional studies, to probe molecular mechanisms at the cell surface. The group's research addresses fundamental questions about cell-cell signaling systems of importance to human health. How are signaling assemblies arranged? Which features are necessary for normal signal transduction into the cell? What mechanisms trigger dysfunctional signaling? The work ties into an extensive network of interdisciplinary local and international collaborations with the ultimate aim of learning how to manipulate these signaling systems for the design of new clinical therapies. Current projects within the group focus on signaling systems of importance in developmental biology. These include semaphorin/plexin/neuropilin ligand-receptor complexes involved in cell guidance as well as mechanisms controlling signaling by the Wnt family of morphogens.

For more information go to https://oir.nih.gov/wals/nih-directors-wednesday-afternoon-lecture-series-2023-2024/dissecting-human-immune-response-useful-basic-surprising-findings