NIH VideoCast - Elucidation and Pharmacological Targeting of Cellular Dependencies at the Single Cell Level

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Elucidation and Pharmacological Targeting of Cellular Dependencies at the Single Cell Level

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Air date:	Wednesday, January 12, 2022, 3:00:00 PM Time displayed is Eastern Time, Washington DC Local
Views:	Total views: 331 (180 Live, 151 On-demand)
Category:	WALS - Wednesday Afternoon Lectures
Runtime:	01:09:13
Closed captioning:	Check box to display CC outside of the video Note: You can drag the captioning window around and resize it
Description:	NIH Wednesday Afternoon Lecture Series Dr. Califano is the Clyde and Helen Wu Professor of Chemical and Systems Biology, chair of the Department of Systems Biology, and director of the JP Sulzberger Columbia Genome Center at the Columbia University Medical Center. A physicist by training, Califano has taken innovative, systematic approaches to identify the molecular factors that lead to cancer progression and to the emergence of drug resistance at the single-cell level. This entails examination of the complex and tumor-specific molecular interaction networks that determine cancer cell behavior. His lab has shown that master regulators represent critical drivers and tumor dependencies, despite the fact that they are rarely mutated or differentially expressed, thus establishing them as a bona fide new class of therapeutic targets. For more information go to https://oir.nih.gov/wals

NLM Title:	Elucidation and pharmacological targeting of cellular dependencies at the single cell level / Andrea Califano.
Author:	Califano, Andrea. National Institutes of Health (U.S.),
Publisher:
Abstract:	(CIT): Dr. Califano is the Clyde and Helen Wu Professor of Chemical and Systems Biology, chair of the Department of Systems Biology, and director of the JP Sulzberger Columbia Genome Center at the Columbia University Medical Center. A physicist by training, Califano has taken innovative, systematic approaches to identify the molecular factors that lead to cancer progression and to the emergence of drug resistance at the single-cell level. This entails examination of the complex and tumor-specific molecular interaction networks that determine cancer cell behavior. His lab has shown that master regulators represent critical drivers and tumor dependencies, despite the fact that they are rarely mutated or differentially expressed, thus establishing them as a bona fide new class of therapeutic targets.
Subjects:	Cell Line, Tumor Cell Transformation, Neoplastic--metabolism Drug Delivery Systems Drug Resistance, Neoplasm Molecular Targeted Therapy Neoplasms--genetics
Publication Types:	Lecture Webcast

NLM Classification:	QZ 203
NLM ID:	9918351573106676
CIT Live ID:	44190
Permanent link:	https://videocast.nih.gov/watch=44190

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