NIH VideoCast - CANCELED - New Roles of Lysosomes in Health and Disease

Air date:	Friday, June 5, 2015, 12:00:00 PM Time displayed is Eastern Time, Washington DC Local
Description:	NIH Director's Seminar Series The discovery that expression of lysosomal genes is not constitutive but changes in response to nutrient status revealed that cells monitor lysosomal function and respond to degradation requirements and environmental conditions. The transcription factors TFEB and TFE3 rapidly translocate from the cytosol to the nucleus following starvation. By regulating expression of numerous genes implicated in lysosomal biogenesis, autophagy, and metabolism, TFEB and TFE3 play a critical role in maintaining cellular homeostasis and energy metabolism. Our recent work reveals that TFEB and TFE3 may have a broader role than previously recognized in cellular response to stress by regulating host immune response to pathogen infection. In addition, the ability of TFEB and TFE3 to induce lysosomal exocytosis and cellular clearance makes them promising therapeutic target for the treatment of lysosomal and neurological disorders.
Author:	Rosa Puertollano Moro, M.S., Ph.D. Senior Investigator, Protein Trafficking and Organelle Biology, NHLBI, NIH
Runtime:	1 hour

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