NIH VideoCast - Molecular Immunology

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Molecular Immunology

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Air date:	Wednesday, March 4, 2015, 4:15:00 PM Time displayed is Eastern Time, Washington DC Local
Views:	Total views: 436 (39 Live, 397 On-demand)
Category:	Immunology
Runtime:	01:02:44
Closed captioning:	Check box to display CC outside of the video Note: You can drag the captioning window around and resize it
Description:	Immunology Interest Group Dr. Erin Adams received her PhD from UC Berkeley for studies of MHC class I evolution in great apes. Her interest in MHC molecules led her to structural and biophysical studies of αβ and γδ T cell receptors and their ligands with Chris Garcia at Stanford. There she developed further her interest in non-classical MHC recognition with the determination of the X-ray structure of a γδ TCR in complex with its non-classical T22 ligand, and also determined the structure of the mouse cytomegalovirus immunoevasin m157 that binds NK receptors. In developing her own program at the University of Chicago, she has focused largely on the structural basis of presentation of glycolipid antigens by CD1d and their recognition by NKT TCR. In the past few years she has explored mycobacterial lipid antigen presentation by CD1c, structural features of the TIM4 regulatory receptor, the contribution of butyrophilin-3 family molecules on regulation of γδ Τ cells, and structural features of MAIT (mucosal associated invariant T) cell TCR recognition of MR-1. Her work draws together a functional and evolutionary perspective on immune recognition with the precision and detail gained from biophysical and structural studies. For more information go to http://sigs.nih.gov/immunology/Pages/default.aspx

NLM Title:	Molecular immunology / Erin J. Adams.
Author:	Adams, Erin J. National Institutes of Health (U.S.). Immunology Interest Group,
Publisher:
Abstract:	(CIT): Immunology Interest Group Dr. Erin Adams received her PhD from UC Berkeley for studies of MHC class I evolution in great apes. Her interest in MHC molecules led her to structural and biophysical studies of [alpha beta] and [gamma delta] T cell receptors and their ligands with Chris Garcia at Stanford. There she developed further her interest in non-classical MHC recognition with the determination of the X-ray structure of a [gamma delta] TCR in complex with its non-classical T22 ligand, and also determined the structure of the mouse cytomegalovirus immunoevasin m157 that binds NK receptors. In developing her own program at the University of Chicago, she has focused largely on the structural basis of presentation of glycolipid antigens by CD1d and their recognition by NKT TCR. In the past few years she has explored mycobacterial lipid antigen presentation by CD1c, structural features of the TIM4 regulatory receptor, the contribution of butyrophilin-3 family molecules on regulation of [gamma delta] cells, and structural features of MAIT (mucosal associated invariant T) cell TCR recognition of MR-1. Her work draws together a functional and evolutionary perspective on immune recognition with the precision and detail gained from biophysical and structural.
Subjects:	Immune System Phenomena Molecular Biology
Publication Types:	Lecture Webcast

NLM Classification:	QW 504
NLM ID:	101655909
CIT Live ID:	15839
Permanent link:	https://videocast.nih.gov/watch=15839

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