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Potentiating signal-responsive transcription: a dynamic dance between paused RNA polymerase and chromatin.

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Air date: Friday, March 01, 2013, 12:00:00 PM
Time displayed is Eastern Time, Washington DC Local
Views: Total views: 151, (52 Live, 99 On-demand)
Category: NIH Director's Seminars
Runtime: 01:05:47
Description: Director's Seminar Series:

Work from the Adelman laboratory has contributed significantly to our understanding of gene regulation, especially within environmentally- or developmentally-responsive networks. The ability to rapidly integrate multiple extra- and intra-cellular signals to produce a specific pattern of gene expression is essential for the growth, development and survival of all organisms; however, the mechanisms that generate and coordinate these responses remain poorly understood. The Adelman laboratory investigates the interplay between environmental stimuli, chromatin architecture and transcription by RNA polymerase II, with a focus on the regulation of early transcription elongation. By expanding our understanding of how cells react to stimuli in a dynamic, yet equilibrated manner, work in the Adelman group has provided fundamental new insights into gene-environment interactions and the mechanisms that maintain normal patterns of gene expression.
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NLM Title: Potentiating signal-responsive transcription : a dynamic dance between paused RNA polymerase and chromatin [electronic resource] / Karen Adelman.
Series: Director's seminar series
Author: Adelman, Karen.
National Institutes of Health (U.S.)
Publisher:
Other Title(s): Director's seminar series
Abstract: (CIT): Director's Seminar Series: Work from the Adelman laboratory has contributed significantly to our understanding of gene regulation, especially within environmentally- or developmentally-responsive networks. The ability to rapidly integrate multiple extra- and intra-cellular signals to produce a specific pattern of gene expression is essential for the growth, development and survival of all organisms; however, the mechanisms that generate and coordinate these responses remain poorly understood. The Adelman laboratory investigates the interplay between environmental stimuli, chromatin architecture and transcription by RNA polymerase II, with a focus on the regulation of early transcription elongation. By expanding our understanding of how cells react to stimuli in a dynamic, yet equilibrated manner, work in the Adelman group has provided fundamental new insights into gene-environment interactions and the mechanisms that maintain normal patterns of gene expression.
Subjects: Chromatin--physiology
DNA-Directed RNA Polymerases--physiology
Transcription, Genetic--physiology
Publication Types: Lectures
Webcasts
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Caption Text: Download Caption File
NLM Classification: QU 475
NLM ID: 101604613
CIT Live ID: 12545
Permanent link: http://videocast.nih.gov/launch.asp?17828