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Network Medicine: From Cellular Interactions to Human Diseases

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Air date: Wednesday, February 06, 2013, 3:00:00 PM
Time displayed is Eastern Time, Washington DC Local
Views: Total views: 363, (146 Live, 217 On-demand)
Category: WALS - Wednesday Afternoon Lectures
Runtime: 01:03:17
Description: Wednesday Afternoon Lecture Series

Given the functional interdependencies between the molecular components in a human cell, a disease is rarely a consequence of an abnormality in a single gene but reflects the perturbations of the complex intracellular network. The emerging tools of network medicine (a holistic approach for investigating networks of interacting molecular and cellular components) offer a platform to systematically explore not only the molecular complexity of a particular disease but also the molecular relationships between apparently distinct (patho)phenotypes. Advances in this direction are essential for identifying new disease genes, uncovering the biological significance of disease-associated mutations identified by genome-wide association studies and full-genome sequencing, and identifying drug targets and biomarkers for complex diseases.
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NLM Title: Network medicine : from cellular interactions to human diseases / Albert-Laszlo Barabasi.
Series: Wednesday afternoon lecture series
Author: Barabási, Albert-László.
National Institutes of Health (U.S.),
Publisher:
Other Title(s): Wednesday afternoon lecture series
Abstract: (CIT): Given the functional interdependencies between the molecular components in a human cell, a disease is rarely a consequence of an abnormality in a single gene but reflects the perturbations of the complex intracellular network. The emerging tools of network medicine (a holistic approach for investigating networks of interacting molecular and cellular components) offer a platform to systematically explore not only the molecular complexity of a particular disease but also the molecular relationships between apparently distinct (patho)phenotypes. Advances in this direction are essential for identifying new disease genes, uncovering the biological significance of disease-associated mutations identified by genome-wide association studies and full-genome sequencing, and identifying drug targets and biomarkers for complex diseases.
Subjects: Cell Physiological Phenomena
Disease--genetics
Gene Regulatory Networks--physiology
Models, Genetic
Publication Types: Lectures
Webcasts
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Caption Text: Download Caption File
NLM Classification: QU 470
NLM ID: 101604596
CIT Live ID: 12299
Permanent link: http://videocast.nih.gov/launch.asp?17792

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