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Given the functional interdependencies between the molecular components in a human cell, a disease is rarely a consequence of an abnormality in a single gene but reflects the perturbations of the complex intracellular network. The emerging tools of network medicine (a holistic approach for investigating networks of interacting molecular and cellular components) offer a platform to systematically explore not only the molecular complexity of a particular disease but also the molecular relationships between apparently distinct (patho)phenotypes. Advances in this direction are essential for identifying new disease genes, uncovering the biological significance of disease-associated mutations identified by genome-wide association studies and full-genome sequencing, and identifying drug targets and biomarkers for complex diseases.
Author:
Albert-Laszlo Barabasi, Ph.D., Northeastern University
