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Epigenetics: How Genes and Environment Interact

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Air date: Wednesday, April 18, 2012, 3:00:00 PM
Time displayed is Eastern Time, Washington DC Local
Views: Total views: 2013, (340 Live, 1673 On-demand)
Category: Wednesday Afternoon Lectures
Runtime: 00:58:00
Description: Human epidemiological and animal experimental data indicate that the risk of developing adult onset diseases and neurological disorders is influenced by persistent adaptations to prenatal and early postnatal environmental exposures. One group of epigenetically regulated genes that potentially links environmental exposures early in development to adult diseases are those with metastable epialleles. These genes have highly variable expression because of stochastic allelic changes in the epigenome rather than mutations in the genome. The viable yellow agouti (Avy) mouse harbors a metastable Agouti gene because of an upstream insertion of a transposable element. We have used the Avy mouse to investigate the importance of epigenetic alterations in determining adult disease risk in response to early developmental exposure to both chemical and physical agents. The importance these studies with regards to human health and disease will be discussed.

The NIH Wednesday Afternoon Lecture Series includes weekly scientific talks by some of the top researchers in the biomedical sciences worldwide.

For more information, visit:
The NIH Director's Wednesday Afternoon Lecture Series
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NLM Title: Epigenetics : how genes and environment interact [electronic resource] / Randy Jirtle.
Series: Wednesday afternoon lecture series
Author: Jirtle, Randy L.
National Institutes of Health (U.S.)
Publisher:
Other Title(s): Wednesday afternoon lecture series
Abstract: (CIT): Human epidemiological and animal experimental data indicate that the risk of developing adult onset diseases and neurological disorders is influenced by persistent adaptations to prenatal and early postnatal environmental exposures. One group of epigenetically regulated genes that potentially links environmental exposures early in development to adult diseases are those with metastable epialleles. These genes have highly variable expression because of stochastic allelic changes in the epigenome rather than mutations in the genome. The viable yellow agouti (Avy) mouse harbors a metastable Agouti gene because of an upstream insertion of a transposable element. We have used the Avy mouse to investigate the importance of epigenetic alterations in determining adult disease risk in response to early developmental exposure to both chemical and physical agents. The importance these studies with regards to human health and disease will be discussed. The NIH Wednesday Afternoon Lecture Series includes weekly scientific talks by some of the top researchers in the biomedical sciences worldwide. For more information, visit: The NIH Director's Wednesday Afternoon Lecture Series.
Subjects: DNA Damage--genetics
Environmental Exposure
Epigenesis, Genetic--genetics
Publication Types: Lectures
Webcasts
Download: To download this event, select one of the available bitrates:
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Caption Text: Download Caption File
NLM Classification: QU 477
NLM ID: 101585237
CIT Live ID: 10520
Permanent link: http://videocast.nih.gov/launch.asp?17223

 

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