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Lecture Summary:
Insufficient time has elapsed for our genomes to adapt to the caloric abundance and reduced physical activity accompanying industrialization. Diseases of dietary excess, rather than nutritional deficiency are the major causes of death and disability in the Western world. Using human genetics, we have identified new genes and sequence variations conferring susceptibility (and resistance) to metabolic disorders associated with diabetes and heart disease.
Lecture Objectives:
1. Review strategies used to identify genetic variants contributing to common diseases associated with dietary excess.
2. Demonstrate role of genes involved in lipid metabolism in susceptibility (and resistance) to metabolic and cardiovascular disease.
3. Appreciate how human genetics can provide mechanistic insights into the relationship between phenotypes and diseases.
Genes versus fast foods : eat, drink and be wary [electronic resource] / Helen Hobbs.
Series:
NIH Director's Wednesday afternoon lecture series
Author:
Hobbs, Helen H. National Institutes of Health (U.S.)
Publisher:
[Bethesda, Md. : National Institutes of Health, 2010]
Other Title(s):
NIH Director's Wednesday afternoon lecture series
Abstract:
(CIT): Lecture Summary: Insufficient time has elapsed for our genomes to adapt to the caloric abundance and reduced physical activity accompanying industrialization. Diseases of dietary excess, rather than nutritional deficiency are the major causes of death and disability in the Western world. Using human genetics, we have identified new genes and sequence variations conferring susceptibility (and resistance) to metabolic disorders associated with diabetes and heart disease. Lecture Objectives: 1. Review strategies used to identify genetic variants contributing to common diseases associated with dietary excess. 2. Demonstrate role of genes involved in lipid metabolism in susceptibility (and resistance) to metabolic and cardiovascular disease. 3. Appreciate how human genetics can provide mechanistic insights into the relationship between phenotypes and diseases. The NIH Director's Wednesday Afternoon Lecture Series includes weekly scientific talks by some of the top researchers in the biomedical sciences worldwide.
Subjects:
Coronary Disease--etiology Fast Foods--adverse effects Fatty Liver--etiology Genetic Predisposition to Disease
