NIH VideoCast - Signaling Pathways That Regulate T Cell Development and Differentiation

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Signaling Pathways That Regulate T Cell Development and Differentiation

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Air date:	Wednesday, October 14, 2009, 4:15:00 PM Time displayed is Eastern Time, Washington DC Local
Views:	Total views: 168 * This only includes stats from October 2011 and forward.
Category:	Immunology
Runtime:	01:10:51
Closed captioning:	Check box to display CC outside of the video Note: You can drag the captioning window around and resize it
Description:	The research in Dr. Berg's laboratory is aimed at understanding the signal transduction pathways important for T lymphocyte development and activation. Using a combination of mouse genetics (transgenics and knockouts), biochemistry, and cellular immunology her current work focuses on three projects: First, characterization of the tyrosine kinase, Jak3, involved in cytokine receptor signaling, using Jak3-deficient mice. These mice have severe defects in lymphocyte development and function. Second, characterization of a novel tyrosine kinase, Itk, involved in T cell receptor signaling. Using Itk-deficient mice generated in the lab she is currently examining the role of this protein in lymphocyte development and activation. Finally, defining the role of Eph receptor tyrosine kinases and their ligands, ephrins, in T lymphocyte maturation. This latter family of proteins is known to play a role in cell migration and tissue patterning during the development of many organ systems in the body; and she is investigating a potential role for these receptor-ligand interactions during thymic development and T cell maturation. The Immunology Interest Group

NLM Title:	Signaling pathways that regulate T cell development and differentiation / Leslie J. Berg.
Author:	Berg, Leslie. National Institutes of Health (U.S.). Immunology Interest Group.
Publisher:
Abstract:	(CIT): The research in Dr. Berg's laboratory is aimed at understanding the signal transduction pathways important for T lymphocyte development and activation. Using a combination of mouse genetics (transgenics and knockouts), biochemistry, and cellular immunology her current work focuses on three projects: First, characterization of the tyrosine kinase, Jak3, involved in cytokine receptor signaling, using Jak3-deficient mice. These mice have severe defects in lymphocyte development and function. Second, characterization of a novel tyrosine kinase, Itk, involved in T cell receptor signaling. Using Itk-deficient mice generated in the lab she is currently examining the role of this protein in lymphocyte development and activation. Finally, defining the role of Eph receptor tyrosine kinases and their ligands, ephrins, in T lymphocyte maturation. This latter family of proteins is known to play a role in cell migration and tissue patterning during the development of many organ systems in the body; and she is investigating a potential role for these receptor-ligand interactions during thymic development and T cell maturation.
Subjects:	Lymphocyte Activation--immunology Protein-Tyrosine Kinases--immunology Receptors, Antigen, T-Cell--immunology Signal Transduction--immunology T-Lymphocytes--immunology
Publication Types:	Lecture Webcast
NLM Classification:	QW 568
NLM ID:	101518971
CIT Live ID:	8129
Permanent link:	https://videocast.nih.gov/watch=8129

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