NIH VideoCast - UT-Heart: Whole Organ Simulations Elucidate Healthy Heart Function and Help Understand Disease Conditions

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UT-Heart: Whole Organ Simulations Elucidate Healthy Heart Function and Help Understand Disease Conditions

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Air date:	Tuesday, March 17, 2009, 10:00:00 AM Time displayed is Eastern Time, Washington DC Local
Views:	Total views: 147 * This only includes stats from October 2011 and forward.
Category:	Special
Runtime:	01:07:00
Closed captioning:	Check box to display CC outside of the video Note: You can drag the captioning window around and resize it
Description:	Systems Biology Speaker Series To promote our understanding of the normal and abnormal function of the heart by integrating our knowledge collected at the molecular and the cellular levels, we have developed a multi-scale and multi-physics computer simulation of the heart. This simulator is based on the finite element method and consists of approximately 0.6 million elements for mechanical computation and 20 million elements for electrophysiology and incorporates mathematical models of cardiac excitation-contraction processes in each element. Its morphology is based on multi-detector CT data and has both ventricles and atria with aortic arch. In our model, fiber orientation was mapped and the conduction system was modeled with characteristic electrophysiology. Upon stimulation applied to the pacemaker site, excitation propagates to the adjacent elements resulting in the synchronous contraction and relaxation of the heart. In addition, because the fluid part representing the blood was also modeled and solved simultaneously with the structural part we can reproduce the blood flow in the atria, ventricles and aorta. Such features of the simulator enable us to extract various data and present them as we do in the clinical laboratories. These data includes ECG, UCG, Doppler ECG, Magneto-cardiogram etc. In the presentation, we will show some preliminary data generated with a diseased heart model. http://www.sml.k.u-tokyo.ac.jp/en/report/report01a.html http://www.nih.gov/sigs/sysbio

NLM Title:	UT-heart : whole organ simulations elucidate healthy heart function and help understand disease conditions / Seiryo Sugiura.
Author:	Sugiura, Seiryo. National Institutes of Health (U.S.)
Publisher:
Abstract:	(CIT): To promote our understanding of the normal and abnormal function of the heart by integrating our knowledge collected at the molecular and the cellular levels, we have developed a multi-scale and multi-physics computer simulation of the heart. This simulator is based on the finite element method and consists of approximately 0.6 million elements for mechanical computation and 20 million elements for electrophysiology and incorporates mathematical models of cardiac excitation-contraction processes in each element. Its morphology is based on multi-detector CT data and has both ventricles and atria with aortic arch. In our model, fiber orientation was mapped and the conduction system was modeled with characteristic electrophysiology. Upon stimulation applied to the pacemaker site, excitation propagates to the adjacent elements resulting in the synchronous contraction and relaxation of the heart. In addition, because the fluid part representing the blood was also modeled and solved simultaneously with the structural part we can reproduce the blood flow in the atria, ventricles and aorta. Such features of the simulator enable us to extract various data and present them as we do in the clinical laboratories. These data includes ECG, UCG, Doppler ECG, Magneto-cardiogram, etc. In the presentation, we will show some preliminary data generated with a diseased heart model. http://www.sml.k.u-tokyo.ac.jp/en/report/report01a.html http://www.nih.gov/sigs/sysbio.
Subjects:	Computer Simulation Heart--physiology Heart--physiopathology
Publication Types:	Lecture Webcast
NLM Classification:	WG 202
NLM ID:	101501607
CIT Live ID:	7567
Permanent link:	https://videocast.nih.gov/watch=7567

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