TARPs and KARPs: Auxiliary Proteins that Modulate AMPA- and Kainate-receptor Kinetics

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Air date:	Monday, January 12, 2009, 12:00:00 PM Time displayed is Eastern Time, Washington DC Local
Views:	Total views: 144 * This only includes stats from October 2011 and forward.
Category:	Neuroscience
Runtime:	01:02:23
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Description:	Dr. James Howe did postdoctoral training with Stuart Cull-Candy and David Colquhoun at University College London before moving to Yale to work with Murdoch Ritchie where he is currently Professor of Pharmacology. Dr. Howe's research on the glutamate receptor ion channels which mediate synaptic transmission in the brain uses biophysical approaches to explore their mechanism of action. Most recently he has worked on how TARPS modulate AMPA receptor function and will present new work on a second family of modulatory proteins for kainate receptors. Selected Publications: Robert, A., Armstrong, N., Gouaux, J.E., and Howe, J.R. (2005). AMPA receptor binding cleft mutations that alter affinity, efficacy, and recovery from desensitization. J. Neurosci. 25:3752-3762. Tomita, S., et al. (2005). Stargazin modulates AMPA receptor gating and trafficking by distinct domains. Nature 435:1052-1058. For more information - NIH Neuroscience Seminar Series

NLM Title:	TARPs and KARPs : auxiliary proteins that modulate AMPA- and kainate-receptor kinetics / James Howe.
Author:	Howe, James. National Institutes of Health (U.S.)
Publisher:
Abstract:	(CIT): Dr. Howe's research on the glutamate receptor ion channels which mediate synaptic transmission in the brain uses biophysical approaches to explore their mechanism of action. Most recently he has worked on how TARPS modulate AMPA receptor function and will present new work on a second family of modulatory proteins for kainate receptors.
Subjects:	Calcium Channels Ion Channel Gating Receptors, AMPA Receptors, Kainic Acid Synaptic Transmission
Publication Types:	Lecture Webcast
NLM Classification:	WL 102.8
NLM ID:	101496155
CIT Live ID:	7133
Permanent link:	https://videocast.nih.gov/watch=7133

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