NIH VideoCast - Immune Regulation in the Intestine

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Immune Regulation in the Intestine

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Air date:	Wednesday, June 25, 2008, 3:00:00 PM Time displayed is Eastern Time, Washington DC Local
Views:	Total views: 206 * This only includes stats from October 2011 and forward.
Category:	WALS - Wednesday Afternoon Lectures
Runtime:	00:56:05
Closed captioning:	Check box to display CC outside of the video Note: You can drag the captioning window around and resize it
Description:	The gastrointestinal tract in humans is colonised by a large number and diverse array of commensal bacteria many of which are beneficial to the host. Most of reside peacefully with our gut residents however a breakdown in intestinal homeostasis can result in inflammatory diseases of the intestine including inflammatory bowel disease, celiacs disease and allergy. In this talk I will review recent work from my own laboratory and others that indicate the intestinal homeostasis is a delicate balance between pro-inflammatory effector responses and immune suppressive regulatory T cells. Analysis of cytokines that drive intestinal inflammation identified IL23 as a master regulator that orchestrates intestinal inflammation via effects on innate cells and T cells. Recent genome wide-association studies have identified polymorphisms in the IL23R as linked to susceptibility to IBD validating IL23 mediated pathways as potential therapeutic targets in IBD. BIOGRAPHICAL SKETCH: Fiona Powrie started her career as a D.Phil student with Don Mason in Oxford before finishing her training as postdoctoral fellow with Dr. R. Coffman at the DNAX research Institute in Palo Alto, California. In 1996 she returned to the UK to establish her own laboratory as a Wellcome Trust Senior Fellow. She is now Professor of Immunology at the Sir William Dunn School of Pathology , Oxford University. Fiona Powrie’s early work identified functionally distinct subsets of CD4+ T cells that could suppress immune responses and whose absence led to inflammatory disease. In the last decade she has focused on immune regulation in the intestine. Her work has identified the functional role of regulatory T cells in intestinal homeostasis and shed light on their development and mechanism of action. She has also shown that both adaptive and innate immune mechanisms contribute to intestinal inflammation and identified the cytokine IL23 as a pivotal player in the pathogenesis of chronic intestinal inflammation. For more information, visit http://www.path.ox.ac.uk/dirsci/immunology/powrie The NIH Director's Wednesday Afternoon Lecture Series includes weekly scientific talks by some of the top researchers in the biomedical sciences worldwide.

NLM Title:	Immune regulation in the intestine / Fiona Powrie.
Author:	Powrie, Fiona. National Institutes of Health (U.S.)
Publisher:
Abstract:	(CIT): The gastrointestinal tract in humans is colonised by a large number and diverse array of commensal bacteria many of which are beneficial to the host. Most of reside peacefully with our gut residents however a breakdown in intestinal homeostasis can result in inflammatory diseases of the intestine including inflammatory bowel disease, celiacs disease and allergy. In this talk I will review recent work from my own laboratory and others that indicate the intestinal homeostasis is a delicate balance between pro-inflammatory effector responses and immune suppressive regulatory T cells. Analysis of cytokines that drive intestinal inflammation identified IL23 as a master regulator that orchestrates intestinal inflammation via effects on innate cells and T cells. Recent genome wide-association studies have identified polymorphisms in the IL23R as linked to susceptibility to IBD validating IL23 mediated pathways as potential therapeutic targets in IBD.
Subjects:	Gastrointestinal Diseases--immunology Gastrointestinal Tract--immunology Gastrointestinal Tract--microbiology
Publication Types:	Lecture Webcast
NLM Classification:	WI 140
NLM ID:	101480532
CIT Live ID:	6741
Permanent link:	https://videocast.nih.gov/watch=6741

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