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Medicine: Mind the Gap - Chaos in the Brickyard - Translational Research in 2007

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Air date: Monday, November 05, 2007, 9:30:00 AM
Time displayed is Eastern Time, Washington DC Local
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Category: Medicine: Mind the Gap
Runtime: 01:29:29
Description: Medicine: Mind the Gap

NIH Office of Disease Prevention Seminar Series

"Chaos in the brickyard" refers to a letter(1) that appeared in Science in 1963, in which Bernard K. Forscher described scientific research as the building of brick edifices:

"Once upon a time, among the activities and occupations of man there was an activity called scientific research and the performers of this activity were called scientists. In reality however, these men were builders who constructed edifices, called explanations or laws, by assembling bricks, called facts…If the bricks were faulty or if they were assembled badly, the edifice would crumble…"

When investigators from basic and clinical fields collaborate to do translational research, special problems arise in determining whether research results should be considered strong. Examples of current problems will be discussed, along with some rules of evidence and broader principles that may help improve translational research.

This new seminar series, Medicine: Mind the Gap, will explore a wide range of issues at the intersection of research, evidence, and clinical practice—-especially areas in which conventional wisdom may lead us astray.

From the role of advocacy organizations in medical research and policy, to off-label drug use, to the effectiveness of continuing medical education, the seminar series will aim to engage the NIH community in thought-provoking discussions to challenge what we *think* we know and to think critically about our role in today’s research environment.

For more information on this seminar series, visit http://consensus.nih.gov/MindtheGap
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NLM Title: Chaos in the brickyard [electronic resource] / David F. Ransohoff.
Series: Medicine: mind the gap lecture series
Author: Ransohoff, David F.
National Institutes of Health (U.S.)
Publisher:
Other Title(s): Medicine: mind the gap lecture series
Abstract: (CIT): "Chaos in the brickyard" refers to a letter that appeared in Science in 1963, in which Bernard K. Forscher described scientific research as the building of brick edifices: "Once upon a time, among the activities and occupations of man there was an activity called scientific research and the performers of this activity were called scientists. In reality however, these men were builders who constructed edifices, called explanations or laws, by assembling bricks, called facts If the bricks were faulty or if they were assembled badly, the edifice would crumble?" When investigators from basic and clinical fields collaborate to do translational research, special problems arise in determining whether research results should be considered strong. Examples of current problems will be discussed, along with some rules of evidence and broader principles that may help improve translational research.
Subjects: Biomedical Research
Evidence-Based Medicine
Reproducibility of Results
Publication Types: Lectures
Webcasts
Download: To download this event, select one of the available bitrates:
[384k]    How to download a Videocast
NLM Classification: W 20.5
NLM ID: 101322984
CIT Live ID: 6157
Permanent link: http://videocast.nih.gov/launch.asp?14124