Novel GPCR Signaling Paradigms in Animal Models

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Air date:	Wednesday, February 21, 2007, 3:00:00 PM Time displayed is Eastern Time, Washington DC Local
Views:	Total views: 186 * This only includes stats from October 2011 and forward.
Category:	WALS - Wednesday Afternoon Lectures
Runtime:	01:04:01
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Description:	G protein-coupled receptors (GPCR) mediate numerous physiological responses. These responses are regulated by kinases (GRKs) followed by binding of the phosphorylated receptors to the scaffold protein, Betta-arrestin. This interaction not only dampens G protein-dependent signaling but also targets receptors for internalization and initiates additional signaling events through the ability of Betta-arrestin to scaffold signaling complexes. In the brain the dopaminergic system is presumably implicated in the control of locomotion, cognition and affect. In mice, activation of D2-like receptors modulates not only the cAMP-dependent signaling pathway but also engages an Akt/PP2A/GSK3 signaling pathway that is mediated by the ability of Betta-arrestin to scaffold these proteins. The NIH Director's Wednesday Afternoon Lecture Series includes weekly scientific talks by some of the top researchers in the biomedical sciences worldwide.

NLM Title:	Novel GPCR signaling paradigms in animal models / Marc G. [i.e. Marc L.] Caron.
Author:	Caron, Marc G. National Institutes of Health (U.S.)
Publisher:
Abstract:	(CIT): G protein-coupled receptors (GPCR) mediate numerous physiological responses. These responses are regulated by kinases (GRKs) followed by binding of the phosphorylated receptors to the scaffold protein, Betta-arrestin. This interaction not only dampens G protein-dependent signaling but also targets receptors for internalization and initiates additional signaling events through the ability of Betta-arrestin to scaffold signaling complexes. In the brain the dopaminergic system is presumably implicated in the control of locomotion, cognition and affect. In mice, activation of D2-like receptors modulates not only the cAMP-dependent signaling pathway but also engages an Akt/PP2A/GSK3 signaling pathway that is mediated by the ability of Betta-arrestin to scaffold these proteins. The NIH Director's Wednesday Afternoon Lecture Series includes weekly scientific talks by some of the top researchers in the biomedical sciences worldwide.
Subjects:	Models, Animal Receptors, G-Protein-Coupled--physiology Signal Transduction--physiology
Publication Types:	Lecture Webcast
NLM Classification:	QU 55.7
NLM ID:	101300947
CIT Live ID:	5189
Permanent link:	https://videocast.nih.gov/watch=5189

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