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The current scientific, ethical, and political debate over stem cells pitches the benefits and limitations of 2 cell types against each other, adult versus embryonic stem cells. These definitions overlook an important aspect of the debate in considering adult stem cell plasticity, gender matters. This is because stem cells or tissues taken from a woman who has been pregnant are likely to contain a mixture of her own cells and those of her fetuses. In this talk, Dr. Bianchi will describe her laboratory's work in both humans and mice that tests the hypothesis that as a result of pregnancy, females naturally acquire a population of stem cells that participate in the repair of maternal organs following specific types of injury.