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Chromatin Organization, Non-Coding RNAs and Dosage Compensation in Drosophila

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Air date: Wednesday, January 25, 2006, 3:00:00 PM
Time displayed is Eastern Time, Washington DC Local
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Category: WALS - Wednesday Afternoon Lectures
Runtime: 01:03:10
Description: MSL proteins and noncoding roX RNAs form complexes that bind hundreds of sites along the single male X chromosome to make X-linked gene expression equal in male and female Drosophila.  MSL complexes are proposed to up-regulate X-linked genes through site-specific acetylation of histone H4 at Lys16.  The roX1 and roX2 RNAs are dissimilar in size and sequence, but are functionally redundant. The roX RNAs are required for normal targeting of the X chromosome, and in their absence MSL complexes bind poorly to the X. 

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The NIH Director's Wednesday Afternoon Lecture Series includes weekly scientific talks by some of the top researchers in the biomedical sciences worldwide.
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Author: Mitzi Kuroda, Harvard Medical School
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CIT Live ID: 4259
Permanent link: http://videocast.nih.gov/launch.asp?13025

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