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Sensing Infection: Toll-Like Receptors and the Genetic Analysis of Mammalian Innate Immunity

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Air date: Wednesday, January 18, 2006, 3:00:00 PM
Time displayed is Eastern Time, Washington DC Local
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Category: Wednesday Afternoon Lectures
Runtime: 00:55:56
Description: Mammals have an inherent capacity to recognize and respond to specific molecules of microbial origin, on a time scale of minutes following inoculation. A detailed understanding of precisely how recognition and response are mediated has stood as one of the principal goals of immunology. Among the molecules recognized, lipopolysaccharide (LPS; endotoxin) has been most widely used to model infection, yet its receptor remained unknown until recently. We identified the receptor for LPS by positionally cloning a locus in mice (Lps) that governed LPS responses. The Lps locus was shown to encode Toll-like receptor 4, a homolog of the Drosophila Toll protein, which had been shown to have both developmental and immunological functions.

For more information, visit
http://www.scripps.edu/research/faculty.php?tsri_id=8340

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Author: Bruce Beutler, M.D., Scripps Research Institute
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CIT Live ID: 4258
Permanent link: http://videocast.nih.gov/launch.asp?13986