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Maintenance of Membrane Integrity During Protein Trafficking at the ER Membrane

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Air date: Wednesday, November 09, 2005, 3:00:00 PM
Time displayed is Eastern Time, Washington DC Local
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Category: Wednesday Afternoon Lectures
Runtime: 01:03:31
Description: In eukaryotic cells, most membrane proteins are integrated into the membrane of the endoplasmic reticulum (ER) co-translationally at sites termed translocons. Each translocon forms an aqueous pore that spans the bilayer, yet the permeability barrier of the ER membrane is maintained during secretory protein translocation or membrane protein integration at the translocon. Small ion movement through the translocon pore during integration is regulated by a complex choreography of interactions between the ribosome, translocon, BiP, and probably other molecular species. We have used fluorescence spectroscopy, fluorescence resonance energy transfer, and photocrosslinking to examine intermediates at various stages of integration.

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NIH Director's Wednesday Afternoon Lecture Series
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Author: Arthur Johnson, Ph.D., Texas A&M
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CIT Live ID: 4251
Permanent link: http://videocast.nih.gov/launch.asp?12890