Messenger Molecules of Life and Death

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Air date:	Wednesday, September 14, 2005, 3:00:00 PM Time displayed is Eastern Time, Washington DC Local
Views:	Total views: 97 * This only includes stats from October 2011 and forward.
Category:	WALS - Wednesday Afternoon Lectures
Runtime:	01:00:11
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Description:	We have elucidated a novel apoptotic cascade whereby diverse forms of cell stress activate inducible NO synthase (iNOS). The generated NO nitrosylates glyceraldehyde-3-phosphate dehydrogenase (GAPDH) abolishing catalytic activity and conferring the ability to bind to Siah. Siah is an ubiquitin-3-ligase which possesses a nuclear localization signal (lacking in GAPDH) and causes the translocation of the two proteins to the nucleus. Within the nucleus GAPDH stabilizes the rapidly turning over Siah. Siah elicits apoptosis by degrading several nuclear proteins. For more information, visit http://neuroscience.jhu.edu/peopledetail.asp?ID=1 NIH Director's Wednesday Afternoon Lecture Series

Author:	Solomon Snyder, M.D., Johns Hopkins School of Medicine
CIT Live ID:	4245
Permanent link:	https://videocast.nih.gov/watch=4245

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