Skip Navigation

The role of mass spectrometry to implement protein biomarkers in clinical studies for precision medicine

Loading video...

179 Views

Air date: Thursday, May 2, 2019, 10:00:00 AM
Time displayed is Eastern Time, Washington DC Local
Views: Total views: 179 (24 Live, 155 On-demand)
Category: Proteomics
Runtime: 00:57:09
Description: Proteomics Interest Group

Understanding cancer biology at a molecular level has dramatically changed therapeutic strategies in oncology and improved patient care. As drugs become more targeted with clearer mode of actions, it is important to implement robust biomarkers into drug development process to precisely identify the right patients for clinical trials, to deliver safer and more effective drugs, and to reduce overall developmental costs. While genetic biomarkers are widely used, implementing protein biomarkers remains challenging in part due to the lack of robust technologies fit for clinical laboratories. Recently, mass spectrometry (MS) has been increasingly applied to clinical studies to overcome major limitations of immunohistochemistry, which is the standard method of protein-based diagnostics. In this lecture, we will discuss how SRM-based protein assays improve clinical studies compared to immuno-assays, and future directions of the MS-based quantitative methodologies for clinical applications with a focus on the emerging DIA-based approach.

For more information go to http://proteome.nih.gov
Author: Yeoun Jin Kim, Ph.D., AstraZeneca
 
CIT Live ID: 31993
Permanent link: https://videocast.nih.gov/watch=31993

Related Videos...

Click Here to Play Video.
08:14:11
INCLUDE Project: Clinical Trials in Down Syndrome Workshop (Day 1)
[Conferences]
5/7/2020
Click Here to Play Video.
06:14:37
Understanding and Restoring Whole Joint Health in Pain Management: An NIH HEAL Initiative Workshop (Day 1)
[Conferences]
7/25/2023
Click Here to Play Video.
06:51:47
Fourth Geroscience Summit: Geroscience for the Next Generation (Day 2)
[Conferences]
4/25/2023
Click Here to Play Video.
06:12:47
NIH Workshop on Catalyzing the Development of Novel Alternatives Methods.
[Advisory Committee to the Director of the NIH]
8/21/2023
Click Here to Play Video.
05:24:53
Bridging the Gap: Clinical and Basic Research to Understand COPD Mechanisms (Day 2)
[Conferences]
6/14/2023
Click Here to Play Video.
06:50:53
Annual Sickle Cell Disease Research FY23 (Day 1)
[Conferences]
8/14/2023
Click Here to Play Video.
04:26:40
Malnutrition in Clinical Settings: Research Gaps and Opportunities - Day 2
[Conferences]
9/13/2022
Click Here to Play Video.
06:48:16
Sleep health and dysfunction across the spectrum of pulmonary vascular disease (Day 1)
[Conferences]
8/30/2023
Click Here to Play Video.
07:17:47
Anti-Beta-Amyloid Passive Immunotherapy for Alzheimer’s Dementia and Amyloid Related Imaging Abnormalities (ARIA): What’s Next? (Day 1)
[Conferences]
9/28/2023
Click Here to Play Video.
05:50:42
Strategies for an HIV Cure (Day 1)
[Conferences]
10/12/2023