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Survival of vertebrate hosts against infections depends on important natural or innate resistance mechanisms combined with adaptive immune responses of T and B cells. Viruses, bacteria or classical parasites all probe the limit of immune responses and of immunity. They offer therefore an excellent opportunity to assess the biology, physiology and molecular aspects of immune responses and help to characterize the three basic parameters of immunology e.g. specificity, tolerance and memory. Various experiments will be summarized that indicate that the rules of anti-viral, anti-tumor, anti-organgraft and of autoimmune responses are basically the same.
