Structural and Digital Biology of Macromolecular Complexes

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Air date:	Wednesday, March 31, 2004, 3:00:00 PM Time displayed is Eastern Time, Washington DC Local
Views:	Total views: 90 * This only includes stats from October 2011 and forward.
Category:	WALS - Wednesday Afternoon Lectures
Runtime:	00:59:47
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Description:	A typical biological process involves tens to hundreds of proteins to act in coordinated and concerted manner. Understanding their mechanism of actions requires the 3-dimensional photos of the complex at different physiological stages. This spatial and temporal information is critical for designing new therapeutic strategy to prevent or cure diseases. Typically a macromolecular complex has a molecular size close to or over one million Daltons. A hybrid of technologies in structural and digital biology is necessary to determine the structures of macromolecular complexes. This lecture will illustrate the combined use of electron cryomicroscopy, x-ray crystallography, bioinformatics and structural prediction to study a variety of macromolecular complexes including viruses, ion channels and machines. Wah Chiu The NIH Director's Wednesday Afternoon Lecture Series

Author:	Wah Chiu, Ph.D., Baylor College of Medicine
Rights:	This is a work of the United States Government. No copyright exists on this material. It may be disseminated freely.
CIT Live ID:	2621
Permanent link:	https://videocast.nih.gov/watch=2621

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