Genetic and RNAi Analysis of C. Elegans Aging

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Air date:	Wednesday, December 3, 2003, 3:00:00 PM Time displayed is Eastern Time, Washington DC Local
Views:	Total views: 108 * This only includes stats from October 2011 and forward.
Category:	WALS - Wednesday Afternoon Lectures
Runtime:	01:02:41
Closed captioning:	Check box to display CC outside of the video Note: You can drag the captioning window around and resize it
Description:	The Florence Mahoney Lecture NIH Director's Wednesday Afternoon Lecture Series. In C. elegans, a network of pathways important for lifespan regulation is starting to emerge. The worm insulin receptor gene regulates whether the animal lives a short life focused on reproduction or instead lives a long life focused on survival and energy storage. Defects in response to insulin also induce a dramatic 2 to 3 fold increase in lifespan. As in humans, insulin in the worm regulates metabolism. This is reminiscent of the increase in mouse and rat lifespan that is induced by low calorie diets, which reduce insulin levels. In both cases, a decline in insulin responses and the ensuing shift in metabolism may slow the aging process by decreasing the production of free radicals. For more information, visit Gary Ruvkun

Author:	Gary Ruvkun, Ph.D., Harvard Medical School
Rights:	This is a work of the United States Government. No copyright exists on this material. It may be disseminated freely.
CIT Live ID:	2591
Permanent link:	https://videocast.nih.gov/watch=2591

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