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The Office of NIH History, the National Institute of Mental Health and the National Institute of Neurological Disorders and Stroke will sponsor a symposium entitled, “NIMH and NINDB Intramural Research in the 1950s,” to draw attention to the historic work of the NIMH and NINDB (today NINDS) Intramural Programs during their first decade of research at the NIH. Speakers and discussants will provide personal recollections about broad scientific ideas and debates, organizational structures at NIH that supported or hindered research, and what caused lines of research to shift from one direction to another.