NIH VideoCast - Long Non-coding RNAs and the Homeostasis of Innate Immune Cells

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Long Non-coding RNAs and the Homeostasis of Innate Immune Cells

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Air date:	Wednesday, April 6, 2016, 4:15:00 PM Time displayed is Eastern Time, Washington DC Local
Views:	Total views: 392 (53 Live, 339 On-demand)
Category:	Immunology
Runtime:	00:52:17
Closed captioning:	Check box to display CC outside of the video Note: You can drag the captioning window around and resize it
Description:	Immunology Interest Group Jorge Henao-Mejia obtained his M.D. in 2005 from the University of Antioquia, Medellin, Colombia and his Ph.D. in 2009 from Indiana University, Indianapolis. He was a post-doctoral fellow with Richard Flavell at Yale University, where he studied the interactions between the immune system and metabolism in the context of health and obesity. Since summer 2014, he has been on the Faculty at the University of Pennsylvania. His current research aims to understand the role of the innate immune system in the development of metabolic syndrome, and to comprehend the metabolic pathways that are necessary for appropriate immune responses. Jorge's laboratory has been pioneering novel mouse genetic tools to define the molecular mechanism of chronic inflammatory disorders, with a particular focus on long non-coding RNAs (see Cold Spring Harb Protoc 2016; doi:10.1101/pdb.prot090704), which he will discuss during his presentation. He is a rising star in the field and his talk is one not to miss. Abstract: Epigenetic modifications induced by extracellular cues enable cells to rapidly adapt to changes in their environment. Long non-coding RNAs (lncRNAs) are now considered key controllers of epigenetically regulated gene expression. Notably, emerging evidence indicates that lncRNAs play a critical role in integrating extracellular inputs with epigenetic modification pathways to promote changes in gene expression programs. Given the tight regulation that is required to maintain innate immune cells on check and prevent the development immunopathology, we propose that highly inflammatory cells specifically express lncRNAs that are required to finely tune these cells to their environment, to both promote anti-pathogen immunity and prevent immunopathology. In here, we combined a novel bioinformatic workflow with the CRISPR/Cas9 system to provide evidence that rapid and local regulation of gene expression by lncRNAs in response to extracellular cues is a powerful and potentially generalizable mechanism through which optimal immune cell homeostasis is achieved.

NLM Title:	Long non-coding RNAs and the homeostasis of innate immune cells / Jorge Henao-Mejia ; Immunology Interest Group.
Author:	Henao-Mejia, Jorge. National Institutes of Health (U.S.). Immunology Interest Group,
Publisher:
Abstract:	(CIT): Immunology Interest Group Jorge Henao-Mejia obtained his M.D. in 2005 from the University of Antioquia, Medellin, Colombia and his Ph.D. in 2009 from Indiana University, Indianapolis. He was a post-doctoral fellow with Richard Flavell at Yale University, where he studied the interactions between the immune system and metabolism in the context of health and obesity. Since summer 2014, he has been on the Faculty at the University of Pennsylvania. His current research aims to understand the role of the innate immune system in the development of metabolic syndrome, and to comprehend the metabolic pathways that are necessary for appropriate immune responses. Jorge's laboratory has been pioneering novel mouse genetic tools to define the molecular mechanism of chronic inflammatory disorders, with a particular focus on long non-coding RNAs (see Cold Spring Harb Protoc 2016; doi:10.1101/pdb.prot090704), which he will discuss during his presentation. He is a rising star in the field and his talk is one not to miss. Abstract: Epigenetic modifications induced by extracellular cues enable cells to rapidly adapt to changes in their environment. Long non-coding RNAs (lncRNAs) are now considered key controllers of epigenetically regulated gene expression. Notably, emerging evidence indicates that lncRNAs play a critical role in integrating extracellular inputs with epigenetic modification pathways to promote changes in gene expression programs. Given the tight regulation that is required to maintain innate immune cells on check and prevent the development immunopathology, we propose that highly inflammatory cells specifically express lncRNAs that are required to finely tune these cells to their environment, to both promote anti-pathogen immunity and prevent immunopathology. In here, we combined a novel bioinformatic workflow with the CRISPR/Cas9 system to provide evidence that rapid and local regulation of gene expression by lncRNAs in response to extracellular cues is a powerful and potentially generalizable mechanism through which optimal immune cell homeostasis is achieved.
Subjects:	Homeostasis Immunity, Innate RNA, Long Noncoding--genetics RNA, Long Noncoding--immunology
Publication Types:	Lecture Webcast

NLM Classification:	QU 58.7
NLM ID:	101682310
CIT Live ID:	18846
Permanent link:	https://videocast.nih.gov/watch=18846

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