Skip Navigation

The Emerging Network of Data for Understanding the Interactions of Genes and Drugs

0 seconds of 0 secondsVolume 90%
Press shift question mark to access a list of keyboard shortcuts
Keyboard Shortcuts
Play/PauseSPACE
Increase Volume↑
Decrease Volume↓
Seek Forward→
Seek Backward←
Captions On/Offc
Fullscreen/Exit Fullscreenf
Mute/Unmutem
Seek %0-9
00:25
00:00
00:00
 

632 Views

Air date: Wednesday, October 12, 2011, 3:00:00 PM
Time displayed is Eastern Time, Washington DC Local
Views: Total views: 632 (146 Live, 486 On-demand)
Category: WALS - Wednesday Afternoon Lectures
Runtime: 00:58:27
Description: The last two decades have provided a flood of data relevant to drug action--from both basic science and clinical sources. These data provide molecular, cellular, tissue, organism and population-level information about how drugs work to create both efficacy and adverse events. Any single data source is imperfect, but integration of these sources can yield remarkable and practical discoveries as well as opportunities for application. In this talk, I describe our recent work using informatics technologies to (1) assess the potential impact of pharmacogenomics in the era of personal genome sequencing, (2) analyze the corpus of published medical literature to extract potentially novel drug interactions along with putative mechanisms, and (3) discover a novel drug-drug interaction that may affect up to 1 million Americans. Together these efforts suggest that informatics-driven science can not only create strong hypotheses, but can provide initial validation, and suggest very focused inexpensive experimental validations.

The NIH Wednesday Afternoon Lecture Series includes weekly scientific talks by some of the top researchers in the biomedical sciences worldwide.

For more information, visit:
The NIH Director's Wednesday Afternoon Lecture Series
NLM Title: The emerging network of data for understanding the interactions of genes and drugs / Russ B. Altman.
Author: Altman, Russ.
National Institutes of Health (U.S.)
Publisher:
Abstract: (CIT): The last two decades have provided a flood of data relevant to drug action--from both basic science and clinical sources. These data provide molecular, cellular, tissue, organism and population-level information about how drugs work to create both efficacy and adverse events. Any single data source is imperfect, but integration of these sources can yield remarkable and practical discoveries as well as opportunities for application. In this talk, I describe our recent work using informatics technologies to (1) assess the potential impact of pharmacogenomics in the era of personal genome sequencing, (2) analyze the corpus of published medical literature to extract potentially novel drug interactions along with putative mechanisms, and (3) discover a novel drug-drug interaction that may affect up to 1 million Americans.
Subjects: Base Sequence--drug effects
Drug Interactions--genetics
Genome--drug effects
Medical Informatics
Pharmacogenetics
Publication Types: Lecture
Webcast
 
NLM Classification: QV 38
NLM ID: 101574445
CIT Live ID: 10504
Permanent link: https://videocast.nih.gov/watch=10504

Related Videos...

Click Here to Play Video.
06:12:47
NIH Workshop on Catalyzing the Development of Novel Alternatives Methods.
[Advisory Committee to the Director of the NIH]
8/21/2023
Click Here to Play Video.
06:50:53
Annual Sickle Cell Disease Research FY23 (Day 1)
[Conferences]
8/14/2023
Click Here to Play Video.
06:48:16
Sleep health and dysfunction across the spectrum of pulmonary vascular disease (Day 1)
[Conferences]
8/30/2023
Click Here to Play Video.
06:28:03
Sleep health and dysfunction across the spectrum of pulmonary vascular disease (Day 2)
[Conferences]
8/31/2023
Click Here to Play Video.
04:35:42
National Institute on Minority Health and Health Disparities Council - September 2023
[Advisory Boards and Councils]
9/1/2023
Click Here to Play Video.
03:26:13
National Advisory Council on Drug Abuse - September 2023
[Advisory Boards and Councils]
9/12/2023
Click Here to Play Video.
04:19:39
National Heart, Lung, and Blood Advisory Council and the Board of External Experts Meeting - September 2023
[Advisory Boards and Councils]
9/12/2023
Click Here to Play Video.
02:44:35
Ethical & Regulatory Aspects of Clinical Research Session 4: Incidental Findings/Return of Results/Inclusion of Native Populations
[Bioethics]
10/11/2023
Click Here to Play Video.
05:15:00
National Advisory Eye Council - October 2023
[Advisory Boards and Councils]
10/13/2023
Click Here to Play Video.
02:27:29
NAGMS May 2024 Council Open Session
[Special]
5/16/2024