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T-Cell Response to TB Infection

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Air date: Wednesday, June 22, 2011, 12:00:00 PM
Time displayed is Eastern Time, Washington DC Local
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Category: Private (world)
Runtime: 00:00:23
Description: Mycobacteria-specific T cells (red) stop migrating after exposure to a mycobacterial antigen (p25) in granulomas of live animals. This arrested movement indicates that the T cells recognize and bind to the antigen. The T-cell response to the added p25 antigen is very strong because almost all the T cells stop moving after its addition.

The green cells are T cells specific to a chicken egg protein used as a control antigen for the experiment. These cells stop moving when the antigen OVA323 is injected into the animals. These results indicate that arrested movement is a general feature of T cell antigen-recognition in granulomas. They also show that this arrested movement is specific for the antigen recognized by a particular T cell.
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Author: NIAID
CIT Live ID: 10344
Permanent link: http://videocast.nih.gov/launch.asp?16723