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Our work is concerned with the formation, function and homeostasis of organs during vertebrate development. We are interested in understanding the cellular and molecular events that underlie cellular differentiation, tissue morphogenesis and organ function during the formation of the cardiovascular system (the heart and the blood vessels) as well as the liver and pancreas. One approach consists of screening for mutations that affect these processes in zebrafish, a vertebrate model system that allows forward genetics as well as embryological studies. We also utilize the tools of chemical genetics to identify pathways that regulate these processes, taking advantage of the high-throughput methods available in zebrafish.
This talk will focus on pancreas development and glucose homeostasis. Specifically, it will address our attempts to increase beta-cell mass via mobilization of stem cells and cell reprogramming. It will also cover the results of our ongoing screens for small molecules designed to 1) enhance beta-cell regeneration, 2) lower gluconeogenesis and 3) enhance beta-cell proliferation. Altogether, these studies aim to provide new therapeutic avenues to treat diabetes.
The NIH Wednesday Afternoon Lecture Series includes weekly scientific talks by some of the top researchers in the biomedical sciences worldwide.
