BEGIN:VCALENDAR VERSION:2.0 PRODID:VideoCast CALSCALE:GREGORIAN METHOD:PUBLISH BEGIN:VEVENT SUMMARY:Self Stimulation—How Positive Feedback Loops Wire the Brain DTSTART:20120509T190000Z DTEND:20120509T200000Z DTSTAMP:20120524T164600Z UID:Videocast--10523 LOCATION:http://videocast.nih.gov DESCRIPTION:Bernardo L. Sabatini\, M.D.\, Ph.D.\, Harvard Medical School Investigator\, Howard Hughes Medical Institute\nA great deal of brain development happens after birth. During this period\, sensory inputs and patterns of activity within the brain drive the refinement of circuits and the formation of synapses. This is well established for parts of the brain that receive signals from the outside world\, such as sensory systems. Much less is known about the function of activity in shaping the development of non-sensory and sub-cortical systems. Dr. Sabatini will show that activity in a recurrent loop between the basal ganglia and cortex acts in a self-reinforcing manner. Thus manipulations that promote the activity of the direct pathway through the basal ganglia\, and hence activate cortex\, lead to greater innervation of the basal ganglia. His lab proposes that such self-reinforcing systems ensure the correct wiring of sub-cortical systems that lack the stereotyped topographic organization of sensory systems. Lastly\, his lab proposes that early perturbations of such mechanisms can contribute to developmental disorders such as cerebral palsy and attention deficit hyperactivity disorder.\n\nThe NIH Wednesday Afternoon Lecture Series includes weekly scientific talks by some of the top researchers in the biomedical sciences worldwide. \n\nFor more information\, visit: \nThe http://wals.od.nih.gov NIH Director's Wednesday Afternoon Lecture Series X-ALT-DESC;FMTTYPE=text/html:\n\n\n

Author: Bernardo L. Sabatini\, M.D.\, Ph.D.\, Harvard Medical School Investigator\, Howard Hughes Medical Institute

Description: A great deal of brain development happens after birth. During this period\, sensory inputs and patterns of activity within the brain drive the refinement of circuits and the formation of synapses. This is well established for parts of the brain that receive signals from the outside world\, such as sensory systems. Much less is known about the function of activity in shaping the development of non-sensory and sub-cortical systems. Dr. Sabatini will show that activity in a recurrent loop between the basal ganglia and cortex acts in a self-reinforcing manner. Thus manipulations that promote the activity of the direct pathway through the basal ganglia\, and hence activate cortex\, lead to greater innervation of the basal ganglia. His lab proposes that such self-reinforcing systems ensure the correct wiring of sub-cortical systems that lack the stereotyped topographic organization of sensory systems. Lastly\, his lab proposes that early perturbations of such mechanisms can contribute to developmental disorders such as cerebral palsy and attention deficit hyperactivity disorder.

The NIH Wednesday Afternoon Lecture Series includes weekly scientific talks by some of the top researchers in the biomedical sciences worldwide.

For more information\, visit:
The NIH Director's Wednesday Afternoon Lecture Series

CIT Live ID: 10523

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