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The tip of the therapeutic iceberg: Expanding the G protein-coupled receptor pharmacopeia

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Air date: Thursday, April 12, 2012, 10:00:00 AM
Time displayed is Eastern Time, Washington DC Local
Views: Total views: 260, (12 Live, 248 On-demand)
Category: Proteomics
Runtime: 01:09:14
Description: Proteomics Interest Group

Currently nearly half of the therapeutic pharmacopeia is targeted towards the plasma membrane heptahelical G proteincoupled receptors (GPCRs). Once considered to be relatively simplisitc ‘on-off’ systems, these highly flexible receptor proteins appear now to possess a potentially unprecedented level of functional nuance. Our increased appreciation of this specific receptor system is undoubtedly one of the most important fields of future translational research for the NIH.
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NLM Title: The tip of the therapeutic iceberg : expanding the G protein-coupled receptor pharmacopeia [electronic resource] / Stuart Maudsley ; Proteomics Interest Group.
Author: Maudsley, Stuart.
National Institutes of Health (U.S.). Proteomics Interest Group.
Publisher:
Abstract: (CIT): Currently nearly half of the therapeutic pharmacopeia is targeted towards the plasma membrane heptahelical G proteincoupled receptors (GPCRs). Once considered to be relatively simplisitc "on-off" systems, these highly flexible receptor proteins appear now to possess a potentially unprecedented level of functional nuance. Our increased appreciation of this specific receptor system is undoubtedly one of the most important fields of future translational research for the NIH.
Subjects: Drug Discovery
Receptors, G-Protein-Coupled--physiology
Publication Types: Lectures
Webcasts
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Caption Text: Download Caption File
NLM Classification: QV 36
NLM ID: 101585228
CIT Live ID: 11155
Permanent link: http://videocast.nih.gov/launch.asp?17209